PMID- 9242213
OWN - NLM
STAT- MEDLINE
DCOM- 19970818
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 97
IP  - 1
DP  - 1997 Aug
TI  - Partial duplication of the MLL gene in acute myelogenous leukemia without 
      karyotypic aberration.
PG  - 20-4
AB  - Partial duplication of the MLL gene is a recently characterized novel genetic 
      mechanism for leukemogenesis. A close association with trisomy 11 has been 
      observed. A case of acute myelogenous leukemia (AML) M6 without karyotypic 
      abnormality was found to have rearrangement of the MLL gene. Southern analysis 
      with an MLL exon 2 probe revealed partial duplication of the MLL gene, with a 
      duplicated MLL transcript amplified by reverse transcription polymerase chain 
      reaction (RT = PCR). The presence of trisomy 11 was excluded by fluorescence in 
      situ hybridization (FISH). Few cases of AML with MLL gene duplication have been 
      reported, and they showed involvement of the M1, M2, and M4 subtypes. This case 
      is the first reported case with an M6 phenotype, and highlights the importance of 
      investigating for MLL gene mutations in all subtypes of AML, as they may carry 
      prognostic significance.
FAU - Kwong, Y L
AU  - Kwong YL
AD  - University Department of Medicine, Queen Mary Hospital, Hong Kong.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KMT2A protein, human)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Aged
MH  - Alternative Splicing
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Exons
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Male
MH  - *Multigene Family
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - Polymerase Chain Reaction
MH  - *Proto-Oncogenes
MH  - *Transcription Factors
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - S0165460896003330 [pii]
AID - 10.1016/s0165-4608(96)00333-0 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1997 Aug;97(1):20-4. doi: 10.1016/s0165-4608(96)00333-0.