PMID- 9243375
OWN - NLM
STAT- MEDLINE
DCOM- 19970919
LR  - 20201221
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 17
IP  - 7
DP  - 1997 Jul
TI  - Poly ICLC enhances the antimalarial activity of chloroquine against 
      multidrug-resistant Plasmodium yoelii nigeriensis in mice.
PG  - 419-23
AB  - Swiss mice infected with multidrug-resistant Plasmodium yoelii nigeriensis were 
      treated with polyinosinic-polycytidylic acid stabilized with polylysine and 
      carboxymethyl cellulose (Poly ICLC), a potent interferon (IFN) inducer and immune 
      enhancer, in combination with chloroquine (CQ), which completely eliminated the 
      malaria parasite from these animals. The enhancement of the antimalarial activity 
      of poly ICLC was found to be completely reversed by the cytochrome P-450 inducer, 
      phenobarbitone. No effect of Nw nitro-L-arginine (NLA), an inhibitor of nitric 
      oxide, was seen on the enhancement of the antimalarial activity of CQ by Poly 
      ICLC. These results suggest the possible involvement of cytochrome P-450 
      enzyme-mediated mechanism in the enhancement of the antimalarial activity of CQ 
      by Poly ICLC.
FAU - Awasthi, A
AU  - Awasthi A
AD  - Central Drug Research Institute, Lucknow, India.
FAU - Mehrotra, S
AU  - Mehrotra S
FAU - Bhakuni, V
AU  - Bhakuni V
FAU - Dutta, G P
AU  - Dutta GP
FAU - Levy, H B
AU  - Levy HB
FAU - Maheshwari, R K
AU  - Maheshwari RK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Antimalarials)
RN  - 0 (Interferon Inducers)
RN  - 25104-18-1 (Polylysine)
RN  - 7KYP9TKT70 (poly ICLC)
RN  - 886U3H6UFF (Chloroquine)
RN  - 9035-51-2 (Cytochrome P-450 Enzyme System)
RN  - K679OBS311 (Carboxymethylcellulose Sodium)
RN  - O84C90HH2L (Poly I-C)
RN  - YQE403BP4D (Phenobarbital)
SB  - IM
MH  - Animals
MH  - Antimalarials/*therapeutic use
MH  - Carboxymethylcellulose Sodium/*analogs & derivatives/therapeutic use
MH  - Chloroquine/*therapeutic use
MH  - Cytochrome P-450 Enzyme System/biosynthesis
MH  - Drug Resistance, Multiple
MH  - Drug Therapy, Combination
MH  - Enzyme Induction
MH  - Interferon Inducers/*therapeutic use
MH  - Mice
MH  - Phenobarbital/therapeutic use
MH  - Plasmodium yoelii/*drug effects
MH  - Poly I-C/*therapeutic use
MH  - Polylysine/*analogs & derivatives/therapeutic use
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - 10.1089/jir.1997.17.419 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 1997 Jul;17(7):419-23. doi: 10.1089/jir.1997.17.419.