PMID- 9243595
OWN - NLM
STAT- MEDLINE
DCOM- 19971007
LR  - 20220317
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 8
IP  - 9-10
DP  - 1997 Jul 7
TI  - Neurokinin-1 receptor antagonist SR140333: a novel type of drug to treat cerebral 
      ischemia.
PG  - 2117-9
AB  - Substance P (SP) has been implicated in immune responses and could increase 
      glutamate release, and inflammatory reactions are known to be able to potentiate 
      ischemic damage. We have previously found that SP was over-expressed in cerebral 
      ischemia and speculated that SP may play a role in exacerbating ischemic damage. 
      In this study, we examined whether a neurokinin-1 (NK-1) receptor antagonist, 
      SR140333, would have an effect on brain ischemia. Intra-cerebroventricular 
      (i.c.v.) administration of SR140333 (30 micrograms) markedly reduced (37.1 +/- 
      7.8%, p < 0.001) infarct volume measured 24 h after focal cerebral ischemia in 
      the rat. The SR140333-treated group also exhibited a significantly improved 
      neurological function reflected by the neurological deficit score. The results 
      represented the first demonstration that a NK-1 receptor antagonist may be a 
      novel type of drug for treatment of cerebral ischemia.
FAU - Yu, Z
AU  - Yu Z
AD  - National Key Laboratory of Medical Neurobiology, Shanghai Medical University, 
      People's Republic of China.
FAU - Cheng, G
AU  - Cheng G
FAU - Huang, X
AU  - Huang X
FAU - Li, K
AU  - Li K
FAU - Cao, X
AU  - Cao X
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Neurokinin-1 Receptor Antagonists)
RN  - 0 (Piperidines)
RN  - 0 (Quinuclidines)
RN  - 153050-21-6 (SR 140333)
SB  - IM
MH  - Animals
MH  - Brain Ischemia/*drug therapy
MH  - Disease Models, Animal
MH  - Male
MH  - *Neurokinin-1 Receptor Antagonists
MH  - Piperidines/*pharmacology
MH  - Quinuclidines/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 1997/07/07 00:00
MHDA- 1997/07/07 00:01
CRDT- 1997/07/07 00:00
PHST- 1997/07/07 00:00 [pubmed]
PHST- 1997/07/07 00:01 [medline]
PHST- 1997/07/07 00:00 [entrez]
AID - 10.1097/00001756-199707070-00006 [doi]
PST - ppublish
SO  - Neuroreport. 1997 Jul 7;8(9-10):2117-9. doi: 10.1097/00001756-199707070-00006.