PMID- 9246409
OWN - NLM
STAT- MEDLINE
DCOM- 19970926
LR  - 20220129
IS  - 0967-3849 (Print)
IS  - 0967-3849 (Linking)
VI  - 5
IP  - 3
DP  - 1997 May
TI  - Comparative mapping of Xp22 genes in hominoids--evolutionary linear instability 
      of their Y homologues.
PG  - 167-76
AB  - Several genes located within or proximal to the human PAR in Xp22 have homologues 
      on the Y chromosome and escape, or partly escape, inactivation. To study the 
      evolution of Xp22 genes and their Y homologues, we applied multicolour 
      fluorescence in situ hybridization (FISH) to comparatively map DNA probes for the 
      genes ANT3, XG, ARSD, ARSE (CDPX), PRK, STS, KAL and AMEL to prometaphase 
      chromosomes of the human species and hominoid apes. We demonstrate that the genes 
      residing proximal to the PAR have a highly conserved order on the higher primate 
      X chromosomes but show considerable rearrangements on the Y chromosomes of 
      hominoids. These rearrangements cannot be traced back to a simple model involving 
      only a single or a few evolutionary events. The linear instability of the Y 
      chromosomes gives some insight into the evolutionary isolation of large parts of 
      the Y chromosomes and thus might reflect the isolated evolutionary history of the 
      primate species over millions of years.
FAU - Glaser, B
AU  - Glaser B
AD  - Institute of Human Genetics and Anthropology, University of Freiburg, Germany.
FAU - Grutzner, F
AU  - Grutzner F
FAU - Taylor, K
AU  - Taylor K
FAU - Schiebel, K
AU  - Schiebel K
FAU - Meroni, G
AU  - Meroni G
FAU - Tsioupra, K
AU  - Tsioupra K
FAU - Pasantes, J
AU  - Pasantes J
FAU - Rietschel, W
AU  - Rietschel W
FAU - Toder, R
AU  - Toder R
FAU - Willmann, U
AU  - Willmann U
FAU - Zeitler, S
AU  - Zeitler S
FAU - Yen, P
AU  - Yen P
FAU - Ballabio, A
AU  - Ballabio A
FAU - Rappold, G
AU  - Rappold G
FAU - Schempp, W
AU  - Schempp W
LA  - eng
GR  - TGM06S01/TI_/Telethon/Italy
GR  - TGM97000/TI_/Telethon/Italy
GR  - HD28009/HD/NICHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Chromosome Res
JT  - Chromosome research : an international journal on the molecular, supramolecular 
      and evolutionary aspects of chromosome biology
JID - 9313452
RN  - 0 (DNA Probes)
SB  - IM
MH  - Animals
MH  - *Biological Evolution
MH  - Chromosome Mapping
MH  - DNA Probes
MH  - Genes
MH  - Haplorhini/*genetics
MH  - Hominidae/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Sequence Homology, Nucleic Acid
MH  - X Chromosome/*genetics
MH  - Y Chromosome/*genetics
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - 10.1023/a:1018490713273 [doi]
PST - ppublish
SO  - Chromosome Res. 1997 May;5(3):167-76. doi: 10.1023/a:1018490713273.