PMID- 9247041
OWN - NLM
STAT- MEDLINE
DCOM- 19970910
LR  - 20051122
IS  - 0369-8114 (Print)
IS  - 0369-8114 (Linking)
VI  - 45
IP  - 2
DP  - 1997 Feb
TI  - Macrophages and respiratory viruses.
PG  - 184-92
AB  - This review highlights some of the interactions between alveolar macrophages and 
      human/swine influenza A viruses, porcine reproductive and respiratory syndrome 
      virus (PRRSV), bovine parainfluenza type-3 (PI-3) virus, bovine respiratory 
      syncytial virus (BRSV) and bovine viral diarrhoea virus (BVDV). In influenza A 
      infection, macrophage-cytokines are believed to mediate the typical 
      constitutional effects and inflammation in the respiratory tract. The same 
      cytokines possibly play a role in influenza-bacterial respiratory disease. PRRSV 
      has a very restricted tropism for alveolar macrophages. The virus causes some 
      secondary infections to be more severe, but this could not be related to impaired 
      macrophage functions. Bovine RSV and PI-3 virus, on the other hand, interfere 
      with selected macrophage functions. In addition, PI-3 virus adversely affects 
      lymphocyte proliferation because it interferes with the accessory role of 
      macrophages. One of the characteristic effects of BVDV on monocytes-macrophages 
      is stimulation of prostaglandin E2 production.
FAU - Van Reeth, K
AU  - Van Reeth K
AD  - Laboratory of Veterinary Virology, Faculty of Veterinary Medicine University of 
      Gent, Merelbeke, Belgium.
FAU - Adair, B
AU  - Adair B
LA  - eng
PT  - Journal Article
PT  - Review
PL  - France
TA  - Pathol Biol (Paris)
JT  - Pathologie-biologie
JID - 0265365
SB  - IM
MH  - Animals
MH  - Diarrhea Viruses, Bovine Viral/immunology
MH  - Humans
MH  - Influenza A virus/immunology
MH  - Macrophages, Alveolar/immunology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/immunology
MH  - Respiratory Syncytial Virus, Bovine/immunology
MH  - Respiratory Tract Infections/*virology
MH  - Respirovirus/immunology
RF  - 74
EDAT- 1997/02/01 00:00
MHDA- 1997/02/01 00:01
CRDT- 1997/02/01 00:00
PHST- 1997/02/01 00:00 [pubmed]
PHST- 1997/02/01 00:01 [medline]
PHST- 1997/02/01 00:00 [entrez]
PST - ppublish
SO  - Pathol Biol (Paris). 1997 Feb;45(2):184-92.