PMID- 9248865
OWN - NLM
STAT- MEDLINE
DCOM- 19970925
LR  - 20131121
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 19
IP  - 3
DP  - 1997 Aug
TI  - Immunoglobulin E and autoantibodies in mercury-exposed workers.
PG  - 383-92
AB  - In this work we have studied the serum immunoglobulin E (IgE) levels and the 
      concentration of anti-DNA and anti-nucleus antibodies in mercury-exposed workers. 
      The study group consisted of 36 workers from a mercury producing plant, with a 
      mean age of 27 years and a mean exposure period to mercury of 19 months. At the 
      time of testing, and for the three previous months, the exposed population had 
      urinary mercury levels below the currently accept limit of 50 ug/g creatinine. 
      Significantly increased IgE levels was found in the mercury-exposed individuals. 
      Moreover, a moderate negative correlation (r = -0.43 P < 0.05) between the length 
      of exposure to mercury and IgE levels was observed. Anti-DNA and anti-nucleus 
      antibodies were not detected in these workers. These results suggest that the 
      humoral immune response is an indicator of cellular changes in workers 
      chronically exposed to mercury, even in those with urinary mercury concentrations 
      within levels considered safe in the occupational area.
FAU - Dantas, D C
AU  - Dantas DC
AD  - Department of Pharmacology, Faculty of Medical Sciences, State University of 
      Campinas, (UNICAMP), Brazil.
FAU - Queiroz, M L
AU  - Queiroz ML
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Antibodies, Antinuclear)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-49-2 (DNA)
RN  - FXS1BY2PGL (Mercury)
SB  - IM
MH  - Adult
MH  - Antibodies, Antinuclear/*blood/drug effects/*immunology
MH  - DNA/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood/drug effects
MH  - Mercury/*adverse effects/*immunology/urine
MH  - Middle Aged
MH  - Occupational Exposure/*adverse effects
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.3109/08923979709046983 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 1997 Aug;19(3):383-92. doi: 
      10.3109/08923979709046983.