PMID- 9249935
OWN - NLM
STAT- MEDLINE
DCOM- 19970911
LR  - 20190914
IS  - 0934-0874 (Print)
IS  - 0934-0874 (Linking)
VI  - 10
IP  - 4
DP  - 1997
TI  - Suppressed alloreactivity and mixed chimerism in rats with accepted cardiac 
      allografts by intrathymic injection of donor bone marrow cells.
PG  - 262-7
AB  - Intrathymic injection of donor bone marrow cells (ITBMCs) at the time of 
      transplantation and treatment with antilymphocyte serum (ALS) permitted the 
      indefinite survival of Brown Norway (BN, RT1n) rat heart grafts in 6 out of 8 
      Lewis (LEW, RT1l) rat recipients, LEW recipients with long-surviving BN heart 
      grafts (LSGs) also accepted additional BN heart grafts without further 
      immunosuppression, though they rejected Piebald Virol Glaxo (PVG, RT1c) rat heart 
      grafts in the usual fashion. In the in vitro study, the proliferative response of 
      the lymphocytes from LEW recipients with LSGs remained suppressed when they were 
      stimulated by BN spleen cells, but not when stimulated by PVG cells. Bone marrow 
      cells (BMCs) from LEW rats with LSGs showed strong, nonspecific, suppressive 
      effects on the proliferative response in the mixed lymphocyte culture reaction, 
      suggesting that one of the possible explanations for tolerance might be the 
      involvement of a suppressor mechanism.
FAU - Matsuura, T
AU  - Matsuura T
AD  - Department of Urology, Osaka Teishin Hospital, Japan.
FAU - Imanishi, M
AU  - Imanishi M
FAU - Hara, Y
AU  - Hara Y
FAU - Nishioka, T
AU  - Nishioka T
FAU - Kunikata, S
AU  - Kunikata S
FAU - Akiyama, T
AU  - Akiyama T
FAU - Kurita, T
AU  - Kurita T
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Transpl Int
JT  - Transplant international : official journal of the European Society for Organ 
      Transplantation
JID - 8908516
SB  - IM
MH  - Animals
MH  - *Bone Marrow Cells
MH  - *Cell Transplantation
MH  - Chimera
MH  - Graft Survival
MH  - Heart Transplantation/*immunology
MH  - *Immune Tolerance
MH  - Lymphocyte Culture Test, Mixed
MH  - Male
MH  - Rats
MH  - Rats, Inbred BN
MH  - Rats, Inbred Lew
MH  - Skin Transplantation
MH  - Transplantation, Homologous
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1007/s001470050055 [doi]
PST - ppublish
SO  - Transpl Int. 1997;10(4):262-7. doi: 10.1007/s001470050055.