PMID- 9250598
OWN - NLM
STAT- MEDLINE
DCOM- 19970905
LR  - 20180216
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 113
IP  - 4
DP  - 1997 Aug
TI  - Eosinophil-derived proteins in postprandial (food-dependent) exercise-induced 
      anaphylaxis.
PG  - 505-11
AB  - BACKGROUND: Postprandial exercise-induced anaphylaxis (PPEIAn) is a form of EIAn 
      in which the ingestion of food before the exercise is associated with the onset 
      of symptoms. Skin reactivity and the presence of specific serum IgE to several 
      food allergens suggest the occurrence of food-dependent allergic mechanisms. 
      METHODS: In order to study the involvement of eosinophils in the pathogenesis of 
      PPEIAn we measured the changes in serum eosinophil cationic protein (ECP) and 
      eosinophil protein X/eosinophil-derived neurotoxin (EPX/EDN) levels in 6 patients 
      with PPEIAn, subjected to three separate challenges with either suspected foods 
      only, exercise after a meal without or with suspected food ingestion. RESULTS: We 
      found serum levels of both eosinophil-derived proteins increased only in 
      challenges including both exercise and suspected food ingestion. Symptoms of 
      anaphylaxis occurred in 3 of these patients. CONCLUSIONS: The increased release 
      of eosinophil basic proteins in PPEIAn patients, caused by physical exercise 
      following ingestion of suspected foods, is not obligatory for the definition of 
      the syndrome.
FAU - Romano, A
AU  - Romano A
AD  - Department of Internal Medicine and Geriatrics, Universita Cattolica del Sacro 
      Cuore, Rome, Italy.
FAU - Fanales-Belasio, E
AU  - Fanales-Belasio E
FAU - Di Fonso, M
AU  - Di Fonso M
FAU - Giuffreda, F
AU  - Giuffreda F
FAU - Palmieri, V
AU  - Palmieri V
FAU - Zeppilli, P
AU  - Zeppilli P
FAU - Ansotegui, I J
AU  - Ansotegui IJ
FAU - Venuti, A
AU  - Venuti A
FAU - Paganelli, R
AU  - Paganelli R
FAU - Aiuti, F
AU  - Aiuti F
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Blood Proteins)
RN  - 0 (Eosinophil Granule Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.- (Eosinophil-Derived Neurotoxin)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anaphylaxis/blood/*immunology
MH  - Blood Proteins/*analysis/immunology
MH  - Eating/immunology
MH  - Eosinophil Granule Proteins
MH  - Eosinophil-Derived Neurotoxin
MH  - Eosinophils/*immunology
MH  - Exercise
MH  - Female
MH  - Food Hypersensitivity/*complications/immunology
MH  - Humans
MH  - Immunoglobulin E/analysis
MH  - Male
MH  - Postprandial Period/immunology
MH  - *Ribonucleases
MH  - Skin Tests
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1159/000237629 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 1997 Aug;113(4):505-11. doi: 10.1159/000237629.