PMID- 9252123
OWN - NLM
STAT- MEDLINE
DCOM- 19970904
LR  - 20190914
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 7
IP  - 1
DP  - 1997 Jul
TI  - Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple 
      HLA-A and HLA-B supertype alleles.
PG  - 97-112
AB  - We recently described human leukocyte antigen (HLA) A2, A3 and B7 supertypes, 
      characterized by largely overlapping peptide-binding specificities and 
      represented in a high percentage of different populations. Here, we identified 17 
      Plasmodium falciparum peptides capable of binding these supertypes and assessed 
      antigenicity in both vaccinated and naturally exposed populations. Positive 
      cytotoxic T lymphocyte recall and cytokine (interferon-gamma and tumor necrosis 
      factor alpha) responses were detected for all peptides; all were recognized in 
      the context of more than one HLA class I molecule; and at least 12 of the 17 were 
      recognized in the context of all HLA alleles studied. These data validate the 
      concept of HLA supertypes at the biological level, show that highly degenerate 
      peptides are almost always recognized as epitopes, and demonstrate the 
      feasibility of developing a universally effective vaccine by focusing on a 
      limited number of peptide specificities.
FAU - Doolan, D L
AU  - Doolan DL
AD  - Malaria Program, Naval Medical Research Institute, Bethesda, Maryland 20889-5670, 
      USA.
FAU - Hoffman, S L
AU  - Hoffman SL
FAU - Southwood, S
AU  - Southwood S
FAU - Wentworth, P A
AU  - Wentworth PA
FAU - Sidney, J
AU  - Sidney J
FAU - Chesnut, R W
AU  - Chesnut RW
FAU - Keogh, E
AU  - Keogh E
FAU - Appella, E
AU  - Appella E
FAU - Nutman, T B
AU  - Nutman TB
FAU - Lal, A A
AU  - Lal AA
FAU - Gordon, D M
AU  - Gordon DM
FAU - Oloo, A
AU  - Oloo A
FAU - Sette, A
AU  - Sette A
LA  - eng
GR  - N01-AI-45241/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (Cytokines)
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Cells, Cultured
MH  - Cytokines/immunology/metabolism
MH  - Epitope Mapping
MH  - Epitopes, T-Lymphocyte/*immunology
MH  - HLA-A Antigens/genetics/*immunology
MH  - HLA-B Antigens/genetics/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Phenotype
MH  - Plasmodium falciparum/*immunology
MH  - Protein Binding
MH  - T-Lymphocytes, Cytotoxic/cytology/*immunology
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - S1074-7613(00)80513-0 [pii]
AID - 10.1016/s1074-7613(00)80513-0 [doi]
PST - ppublish
SO  - Immunity. 1997 Jul;7(1):97-112. doi: 10.1016/s1074-7613(00)80513-0.