PMID- 9253161
OWN - NLM
STAT- MEDLINE
DCOM- 19970904
LR  - 20220227
IS  - 0263-6484 (Print)
IS  - 0263-6484 (Linking)
VI  - 15
IP  - 2
DP  - 1997 Jun
TI  - Effects of retinoids on the production of tumour necrosis factor-alpha and nitric 
      oxide by lipopolysaccharide-stimulated rat Kupffer cells in vitro: evidence for 
      participation of retinoid X receptor signalling pathway.
PG  - 95-101
AB  - Kupffer cells play important roles in the development of liver injury by 
      producing cytokines and free radicals. In consequence inhibition of these 
      inflammatory mediators will be one of the targets for treating liver diseases. 
      Retinoids modulate a wide variety of functions of monocytes/macrophages. Cellular 
      effects of retinoids are mediated by two families of nuclear receptors, retinoic 
      acid receptors (RARs) and retinoid X receptors (RXRs). We examined the effects of 
      several kinds of natural and synthetic retinoids on the production of tumour 
      necrosis factor-alpha (TNF-alpha) and nitric oxide (NO) by LPS-stimulated rat 
      Kupffer cells in vitro. Of the various retinoids tested, 9-cis-retinoic acid 
      (9-cis-RA) and Ro 13-6307 which are agonists of both RARs and RXRs, suppressed 
      the production of TNF-alpha and NO in a concentration-dependent fashion, whereas 
      three types of RAR-selective agonists, Ro 13-7410, Ro 40-6055 and Ro 19-0645 did 
      not show any effect. Furthermore, the RAR alpha antagonist, Ro 41-5253, did not 
      prevent the effects induced by 9-cis-RA. The results suggest that these effects 
      of 9-cis RA and Ro 13-6307 were induced by the RXRs-dependent signalling pathway.
FAU - Motomura, K
AU  - Motomura K
AD  - Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, 
      Fukuoka, Japan.
FAU - Sakai, H
AU  - Sakai H
FAU - Isobe, H
AU  - Isobe H
FAU - Nawata, H
AU  - Nawata H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cell Biochem Funct
JT  - Cell biochemistry and function
JID - 8305874
RN  - 0 (Benzoates)
RN  - 0 (Chromans)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Rara protein, rat)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoic Acid Receptor alpha)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
RN  - 0 (Teratogens)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 144092-31-9 (Ro 41-5253)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 79073-31-7 (Ro 13-6307)
SB  - IM
MH  - Animals
MH  - Benzoates/pharmacology
MH  - Chromans/pharmacology
MH  - Fatty Acids, Unsaturated/pharmacology
MH  - In Vitro Techniques
MH  - Kupffer Cells/*drug effects/*metabolism
MH  - Lipopolysaccharides/*pharmacology
MH  - Male
MH  - Nitric Oxide/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Retinoic Acid/antagonists & inhibitors/physiology
MH  - Retinoic Acid Receptor alpha
MH  - Retinoid X Receptors
MH  - Retinoids/*pharmacology
MH  - Signal Transduction/drug effects/physiology
MH  - Teratogens/pharmacology
MH  - Transcription Factors/physiology
MH  - Tumor Necrosis Factor-alpha/*biosynthesis/*drug effects
EDAT- 1997/06/01 00:00
MHDA- 2000/06/20 09:00
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.1002/(SICI)1099-0844(19970601)15:2<95::AID-CBF727>3.0.CO;2-8 [pii]
AID - 10.1002/(SICI)1099-0844(19970601)15:2<95::AID-CBF727>3.0.CO;2-8 [doi]
PST - ppublish
SO  - Cell Biochem Funct. 1997 Jun;15(2):95-101. doi: 
      10.1002/(SICI)1099-0844(19970601)15:2<95::AID-CBF727>3.0.CO;2-8.