PMID- 9253601
OWN - NLM
STAT- MEDLINE
DCOM- 19970918
LR  - 20190606
IS  - 1088-9051 (Print)
IS  - 1088-9051 (Linking)
VI  - 7
IP  - 7
DP  - 1997 Jul
TI  - A transcript map for the 2.8-Mb region containing the multiple endocrine 
      neoplasia type 1 locus.
PG  - 725-35
AB  - Multiple endocrine neoplasia type 1 (MEN 1) is an inherited cancer syndrome in 
      which affected individuals develop multiple parathyroid, enteropancreatic, and 
      pituitary tumors. The locus for MEN1 is tightly linked to the marker PYGM on 
      chromosome 11q13, and linkage analysis places the MEN1 gene within a 2-Mb 
      interval flanked by the markers D11S1883 and D11S449. Loss of heterozygosity 
      studies in MEN 1 and sporadic tumors suggest that the MEN1 gene encodes a tumor 
      suppressor and have helped to narrow the location of the gene to a 600-kb 
      interval between PYGM and D11S449. Focusing on this smaller MEN1 interval, we 
      have identified and mapped 12 transcripts to this 600-kb region. A precise 
      ordered map of 33 transcripts, including 12 genes known to map to this region, 
      was generated for the 2.8-Mb D11S480-D11S913 interval. Fifteen candidate genes 
      (of which 10 were examined exhaustively) were evaluated by Southern blot and/or 
      dideoxy fingerprinting analysis to identify the gene harboring disease-causing 
      mutations.
FAU - Guru, S C
AU  - Guru SC
FAU - Agarwal, S K
AU  - Agarwal SK
FAU - Manickam, P
AU  - Manickam P
FAU - Olufemi, S E
AU  - Olufemi SE
FAU - Crabtree, J S
AU  - Crabtree JS
FAU - Weisemann, J M
AU  - Weisemann JM
FAU - Kester, M B
AU  - Kester MB
FAU - Kim, Y S
AU  - Kim YS
FAU - Wang, Y
AU  - Wang Y
FAU - Emmert-Buck, M R
AU  - Emmert-Buck MR
FAU - Liotta, L A
AU  - Liotta LA
FAU - Spiegel, A M
AU  - Spiegel AM
FAU - Boguski, M S
AU  - Boguski MS
FAU - Roe, B A
AU  - Roe BA
FAU - Collins, F S
AU  - Collins FS
FAU - Marx, S J
AU  - Marx SJ
FAU - Burns, L
AU  - Burns L
FAU - Chandrasekharappa, S C
AU  - Chandrasekharappa SC
LA  - eng
SI  - GENBANK/AF001433
SI  - GENBANK/AF001434
SI  - GENBANK/AF001435
SI  - GENBANK/AF001436
SI  - GENBANK/AF001540
SI  - GENBANK/AF001541
SI  - GENBANK/AF001542
SI  - GENBANK/AF001543
SI  - GENBANK/AF001544
SI  - GENBANK/AF001545
SI  - GENBANK/AF001546
SI  - GENBANK/AF001547
SI  - GENBANK/AF001891
SI  - GENBANK/AF001892
SI  - GENBANK/AF001893
GR  - HG00313/HG/NHGRI NIH HHS/United States
PT  - Letter
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genome Res
JT  - Genome research
JID - 9518021
SB  - IM
MH  - *Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - Genetic Linkage
MH  - *Genome, Human
MH  - Humans
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Transcription, Genetic
PMC - PMC310681
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
PMCR- 1998/01/01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
PHST- 1998/01/01 00:00 [pmc-release]
AID - 10.1101/gr.7.7.725 [doi]
PST - ppublish
SO  - Genome Res. 1997 Jul;7(7):725-35. doi: 10.1101/gr.7.7.725.