PMID- 92540
OWN - NLM
STAT- MEDLINE
DCOM- 19800215
LR  - 20190827
IS  - 0340-5354 (Print)
IS  - 0340-5354 (Linking)
VI  - 221
IP  - 2
DP  - 1979 Aug
TI  - Hyperacute experimental allergic encephalomyelitis in rhesus monkeys as a model 
      of acute necrotizing hemorrhagic encephalomyelitis.
PG  - 113-25
AB  - A comparative study of clinical and morphological findings in three fatal cases 
      of acute necrotizing hemorrhagic encephalomyelitis (ANHE) and hyperacute 
      experimental allergic encephalomyelitis (HEAE) in rhesus monkeys is reported. In 
      all cases ANHE was characterized clinically by definite prodromal respiratory 
      infection. The course was rapidly progressive with fatal termination. The salient 
      histopathological changes were necrosis of blood vessels with plasma exudation 
      and fibrin impregnation, hemorrhages and inflammatory reaction in the damaged 
      cerebral tissue. Perivascular lymphoid histiocytic infiltration with glial 
      proliferation was also noted in all cases. Numerous compound granular cells were 
      found in one case. HEAE was detected in five rhesus monkeys immunized with 
      homological spinal cord emulsion with complete Freund adjuvant. The illness was 
      acute or subacute and the course was rapidly progressive with a fatal end. There 
      was multiple necrosis of small blood vessels with plasma exudation, fibrin 
      impregnation and massive neutrophila infiltration of the damaged brain tissue in 
      all rhesus monkeys with HEAE. There was also widespread glial proliferation and 
      numerous compound granular cells alongside with necrosis of blood vessels in the 
      brain. These findings suggest that HEAE in rhesus monkeys can be viewed as an 
      adequate model of ANHE.
FAU - Ravkina, L
AU  - Ravkina L
FAU - Harib, I
AU  - Harib I
FAU - Manovitch, Z
AU  - Manovitch Z
FAU - Deconenko, E
AU  - Deconenko E
FAU - Letchinskaja, E
AU  - Letchinskaja E
FAU - Papilova, E
AU  - Papilova E
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Animals
MH  - Brain/*pathology
MH  - Diagnosis, Differential
MH  - *Disease Models, Animal
MH  - Encephalomyelitis/*pathology
MH  - Encephalomyelitis, Autoimmune, Experimental/diagnosis/*pathology
MH  - Female
MH  - Humans
MH  - Leukoencephalitis, Acute Hemorrhagic/diagnosis/*pathology
MH  - *Macaca
MH  - *Macaca mulatta
MH  - Male
MH  - Middle Aged
EDAT- 1979/08/01 00:00
MHDA- 1979/08/01 00:01
CRDT- 1979/08/01 00:00
PHST- 1979/08/01 00:00 [pubmed]
PHST- 1979/08/01 00:01 [medline]
PHST- 1979/08/01 00:00 [entrez]
AID - 10.1007/BF00313109 [doi]
PST - ppublish
SO  - J Neurol. 1979 Aug;221(2):113-25. doi: 10.1007/BF00313109.