PMID- 9254108
OWN - NLM
STAT- MEDLINE
DCOM- 19971002
LR  - 20190831
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 57
IP  - 2
DP  - 1997 Jul
TI  - Inhibitory effects of Korean folk medicine 'Hi-Chum' on histamine release from 
      mast cells in vivo and in vitro.
PG  - 73-9
AB  - The effect of aqueous extract of Siegesbeckia glabrescence (Compositae) whole 
      plants (SGWP) on systemic or local anaphylaxis was studied. SGWP inhibited 
      compound 48/80-induced systemic anaphylaxis 100% with a dose of 1000 mg/kg. Oral 
      administration of SGWP (100 mg/kg) showed a marked inhibition rate in local 
      immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction. When SGWP 
      was pretreated at concentration ranging from 0.1 to 1000 mg/kg, the serum 
      histamine levels were reduced in a dose-dependent manner. Moreover, SGWP 
      dose-dependently inhibited the histamine release from peritoneal mast cells by 
      compound 48/80. These results indicate that SGWP possess strong antianaphylactic 
      activity by inhibition of histamine release from mast cells.
FAU - Kang, B K
AU  - Kang BK
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, South Korea.
FAU - Lee, E H
AU  - Lee EH
FAU - Kim, H M
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Histamine H1 Antagonists)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
SB  - IM
MH  - Anaphylaxis/prevention & control
MH  - Animals
MH  - Histamine H1 Antagonists/*pharmacology
MH  - Histamine Release/*drug effects
MH  - Immunoglobulin E/immunology
MH  - Mast Cells/*drug effects/metabolism
MH  - *Medicine, Traditional
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plants, Medicinal
MH  - Rats
MH  - Rats, Wistar
MH  - p-Methoxy-N-methylphenethylamine/pharmacology
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - S0378-8741(97)00047-0 [pii]
AID - 10.1016/s0378-8741(97)00047-0 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 1997 Jul;57(2):73-9. doi: 10.1016/s0378-8741(97)00047-0.