PMID- 9255481
OWN - NLM
STAT- MEDLINE
DCOM- 19970929
LR  - 20190721
IS  - 0105-1873 (Print)
IS  - 0105-1873 (Linking)
VI  - 37
IP  - 1
DP  - 1997 Jul
TI  - Effect of a topical corticosteroid, a retinoid and a vitamin D3 derivative on 
      sodium dodecyl sulphate induced skin irritation.
PG  - 19-26
AB  - Exposure of the skin to sodium dodecyl sulfate (SDS) leads to disruption of 
      barrier and skin irritation. We used repetitive short exposure to a low molarity 
      SDS solution as an in vivo model to mimic the development of irritant contact 
      dermatitis. In this model, we studied clinical (erythema), functional 
      (transepidermal water loss(TEWL)) and cell biological changes. 24 healthy 
      volunteers were patch tested with SDS (0.2%) for 4 h a day for 5 consecutive 
      days. After removal of the patches, the exposed sites were treated 1 X daily 
      either with a topical corticosteroid (triamcinolon acetonide cream 0.05%), a 
      retinoid (tretinoin cream 0.025%), or a vitamin D3 derivative (calcipotriol 
      ointment 50 micrograms/g). Irritant reactions were assessed by erythema scoring 
      and measurement of barrier function with TEWL up to 14 days after the first 
      challenge. Skin biopsies were taken for cell biological changes at day 4. 
      Vehicle-treated sites served as controls. Repetitive exposure of human skin to 
      SDS resulted in a gradual increase in erythema scoring and TEWL associated with 
      the upregulation of proliferative cells as measured by the expression of 
      Ki-67-antigen and of differentiation markers, visualized by increased expression 
      of involucrin and epidermal-fatty-acid binding protein (E-FABP). Skin irritation 
      as assessed by erythema scoring and TEWL was not significantly suppressed by 
      triamcinolone cream. However, a significant reduction of the number of cycling 
      keratinocytes and a decrease in involucrin positive cell layers was observed in 
      this group. Neither treatment with calcipotriol ointment nor with tretinoin cream 
      induced improvement of skin irritation as judged by visual scoring and TEWL. In 
      contrast to steroid treatment, no significant effect of calcipotriol ointment or 
      tretinoin cream treatment was observed with regard to the number of cycling cells 
      and differentiation markers. Further studies are needed to assess whether 
      treatment with topical corticosteroids is an effective modality in skin 
      irritation and irritant contact dermatitis.
FAU - Le, T K
AU  - Le TK
AD  - Department of Dermatology, University Hospital Nijmegen, The Netherlands.
FAU - De Mon, P
AU  - De Mon P
FAU - Schalkwijk, J
AU  - Schalkwijk J
FAU - van der Valk, P G
AU  - van der Valk PG
LA  - eng
PT  - Journal Article
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Dermatologic Agents)
RN  - 0 (Glucocorticoids)
RN  - 0 (Irritants)
RN  - 0 (Keratolytic Agents)
RN  - 0 (Ointments)
RN  - 0 (Surface-Active Agents)
RN  - 143NQ3779B (calcipotriene)
RN  - 368GB5141J (Sodium Dodecyl Sulfate)
RN  - 5688UTC01R (Tretinoin)
RN  - F446C597KA (Triamcinolone Acetonide)
RN  - FXC9231JVH (Calcitriol)
SB  - IM
MH  - Administration, Topical
MH  - Adult
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Biopsy, Needle
MH  - Calcitriol/administration & dosage/*analogs & derivatives
MH  - Cell Division
MH  - Dermatitis, Irritant/*drug therapy/etiology/pathology/physiopathology
MH  - Dermatologic Agents/*administration & dosage
MH  - Female
MH  - Glucocorticoids
MH  - Humans
MH  - *Irritants
MH  - Keratolytic Agents/*administration & dosage
MH  - Male
MH  - Middle Aged
MH  - Ointments
MH  - Skin/pathology
MH  - Sodium Dodecyl Sulfate/*adverse effects
MH  - Surface-Active Agents/*adverse effects
MH  - Tretinoin/*administration & dosage
MH  - Triamcinolone Acetonide/*administration & dosage
MH  - Water Loss, Insensible
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - 10.1111/j.1600-0536.1997.tb00369.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 1997 Jul;37(1):19-26. doi: 
      10.1111/j.1600-0536.1997.tb00369.x.