PMID- 9257659
OWN - NLM
STAT- MEDLINE
DCOM- 19970828
LR  - 20191024
IS  - 1077-9450 (Print)
IS  - 1077-9450 (Linking)
VI  - 15
IP  - 3
DP  - 1997 Jul 1
TI  - HTLV-I and HTLV-II infections in hematologic disorder patients, cancer patients, 
      and healthy individuals from Rio de Janeiro, Brazil.
PG  - 238-42
AB  - To clarify the seroprevalence of human T-cell lymphotropic virus type I (HTLV-I) 
      among hematologic and cancer patients in the State of Rio de Janeiro, Brazil, we 
      investigated sera from 2430 individuals from the following groups: 152 patients 
      with T-cell diseases, 250 with B-cell disorders, 67 with myeloid leukemia, 41 
      with Hodgkin's disease, 351 with a history of multiple blood transfusions, 235 
      patients with solid tumors of different types, and 109 family members of 
      HTLV-I-infected patients. Antibodies to HTLV-I were screened by enzyme-linked 
      immunosorbent assay or particle agglutination assays (or both). Repeatedly 
      reactive samples were tested by Western blot and polymerase chain reaction assay 
      to differentiate HTLV-I from HTLV-II. We found an increased seroprevalence rate 
      of HTLV-I among those with lymphoid malignancies, mainly in T-cell diseases 
      (28.9%), and these results were important in characterizing 44 cases of adult 
      T-cell leukemia/lymphoma. We confirmed the presence of HTLV-I and HTLV-II 
      infections in blood donors (0.4% and 0.1%, respectively), in patients exposed to 
      multiple blood transfusions (10.2% and 0.8%, respectively), and in 30 (27.5%) of 
      109 family members of HTLV-I- or HTLV-II-infected patients. We also confirmed the 
      high rate occurrence of adult T-cell leukemia/lymphoma among lymphoproliferative 
      disorders in Rio de Janeiro, Brazil.
FAU - Farias de Carvalho, S M
AU  - Farias de Carvalho SM
AD  - Cell Markers Laboratory of Instituto Nacional do Cancer, Rio de Janeiro, Brazil.
FAU - Pombo de Oliveira, M S
AU  - Pombo de Oliveira MS
FAU - Thuler, L C
AU  - Thuler LC
FAU - Rios, M
AU  - Rios M
FAU - Coelho, R C
AU  - Coelho RC
FAU - Rubim, L C
AU  - Rubim LC
FAU - Silva, E M
AU  - Silva EM
FAU - Reis, A M
AU  - Reis AM
FAU - Catovsky, D
AU  - Catovsky D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr Hum Retrovirol
JT  - Journal of acquired immune deficiency syndromes and human retrovirology : 
      official publication of the International Retrovirology Association
JID - 9501482
RN  - 0 (DNA, Viral)
RN  - 0 (HTLV-I Antibodies)
RN  - 0 (HTLV-II Antibodies)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Blood Donors
MH  - Brazil/epidemiology
MH  - DNA, Viral/analysis
MH  - Female
MH  - HTLV-I Antibodies/analysis
MH  - HTLV-I Infections/complications/*epidemiology/immunology
MH  - HTLV-II Antibodies/analysis
MH  - HTLV-II Infections/complications/*epidemiology/immunology
MH  - Hematologic Diseases/*complications
MH  - *Human T-lymphotropic virus 1/genetics/immunology
MH  - *Human T-lymphotropic virus 2/genetics/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*complications
MH  - Prevalence
MH  - Retrospective Studies
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - 10.1097/00042560-199707010-00008 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Jul 1;15(3):238-42. doi: 
      10.1097/00042560-199707010-00008.