PMID- 9258961
OWN - NLM
STAT- MEDLINE
DCOM- 19970926
LR  - 20190909
IS  - 0887-8994 (Print)
IS  - 0887-8994 (Linking)
VI  - 16
IP  - 4
DP  - 1997 May
TI  - Characteristic neuropathology of leukomalacia in extremely low birth weight 
      infants.
PG  - 296-300
AB  - Extremely low birth weight (ELBW) infants with periventricular leukomalacia (PVL) 
      were examined by neuropathological and immunohistochemical methods. Thirteen ELBW 
      infants of 85 infants with PVL, born at 23 to 27 weeks of gestation, showed a 
      widespread type of distribution of PVL from the deep to intermediate white 
      matter. Immunohistochemistry demonstrated glial fibrillary acidic protein 
      (GFAP)-positive astrocytes to be increased in the deep white matter, often 
      spreading to the intermediate white matter, in all cases of PVL. Tumor necrosis 
      factor-alpha (TNF-alpha)-positive cells were found in the deep to intermediate 
      white matter in 69% of PVL cases and appeared earlier, from 23 weeks of 
      gestation, than in controls. beta-Amyloid precursor protein (beta APP)-positive 
      axons were found around PVL in the deep to intermediate white matter in 85% of 
      the cases. In age-matched control ELBW infants, GFAP-, TNF-alpha-, or beta 
      APP-positive cells were never found. Therefore, in ELBW infants, widespread 
      axonal damage and glial activation with cytokine production occur in the 
      progression in characteristic PVL lesions.
FAU - Deguchi, K
AU  - Deguchi K
AD  - Department of Mental Retardation and Birth Defect Research, National Institute of 
      Neuroscience, Tokyo, Japan.
FAU - Oguchi, K
AU  - Oguchi K
FAU - Takashima, S
AU  - Takashima S
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Pediatr Neurol
JT  - Pediatric neurology
JID - 8508183
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Amyloid beta-Protein Precursor/*analysis
MH  - Astrocytes/chemistry/pathology
MH  - Axons/chemistry/pathology
MH  - Glial Fibrillary Acidic Protein/*analysis
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Infant, Newborn
MH  - *Infant, Very Low Birth Weight
MH  - Leukomalacia, Periventricular/metabolism/*pathology
MH  - Microglia/chemistry/pathology
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 1997/05/01 00:00
MHDA- 1997/05/01 00:01
CRDT- 1997/05/01 00:00
PHST- 1997/05/01 00:00 [pubmed]
PHST- 1997/05/01 00:01 [medline]
PHST- 1997/05/01 00:00 [entrez]
AID - S0887899497000416 [pii]
AID - 10.1016/s0887-8994(97)00041-6 [doi]
PST - ppublish
SO  - Pediatr Neurol. 1997 May;16(4):296-300. doi: 10.1016/s0887-8994(97)00041-6.