PMID- 9259956
OWN - NLM
STAT- MEDLINE
DCOM- 19970918
LR  - 20041117
IS  - 0003-3995 (Print)
IS  - 0003-3995 (Linking)
VI  - 40
IP  - 2
DP  - 1997
TI  - Combined use of cytogenetic analysis and FISH for the identification of two 
      antenatal de novo markers as Robertsonian translocations involving the p arms.
PG  - 99-103
AB  - In two prenatal cases, de novo nonmosaic bisatellited marker chromosomes were 
      studied with the combined use of fluorescence in situ hybridization (FISH) with 
      chromosome specific probes and cytogenetic heteromorphisms. The FISH studies 
      showed that one of the small accessory chromosome could be a heterozygous 14/15 
      or 15/22 translocation involving the p arms of these chromosomes, the other 
      showed only one hybridization spot with the classical satellite probe of 
      chromosome 15. The analysis of heteromorphisms of the parental acrocentric 
      chromosomes demonstrated that the two markers were Robertsonian translocations 
      involving in the first case the p arms of the maternal 15 and 22 chromosomes and 
      in the second case the p arms of the maternal 14 and 15 chromosomes.
FAU - Pierluigi, M
AU  - Pierluigi M
AD  - Center of Human Genetics, Galliera Hospital, Genova, Italy.
FAU - Battaglia, P
AU  - Battaglia P
FAU - Perfumo, C
AU  - Perfumo C
FAU - Baroncini, A
AU  - Baroncini A
FAU - Bricarelli, F D
AU  - Bricarelli FD
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Ann Genet
JT  - Annales de genetique
JID - 0370562
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - *Chromosomes, Human, Pair 14
MH  - *Chromosomes, Human, Pair 15
MH  - *Chromosomes, Human, Pair 22
MH  - Female
MH  - *Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Prenatal Diagnosis/*methods
MH  - *Translocation, Genetic
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PST - ppublish
SO  - Ann Genet. 1997;40(2):99-103.