PMID- 9259997
OWN - NLM
STAT- MEDLINE
DCOM- 19971014
LR  - 20191024
IS  - 0951-6433 (Print)
IS  - 0951-6433 (Linking)
VI  - 6
IP  - 2
DP  - 1997
TI  - Effects of plasma lipoproteins on the production of superoxide anion by human 
      polymorphonuclear leukocytes in vitro.
PG  - 157-63
AB  - Polymorphonuclear leukocytes (PMN) generate highly reactive oxygen derived free 
      radicals that may cause lipoprotein lipid oxidation and so contribute to the 
      pathogenesis of atherosclerosis. On the other hand it has been shown that 
      lipoproteins can alter cell functions in vitro. We therefore studied the effects 
      of atherogenic lipoproteins, VLDL and LDL, on the production of superoxide anion 
      by human PMN in the presence or absence of formyl-methionyl-leucyl-phenylalanine 
      (fMLP). VLDL and LDL stimulate PMN superoxide production and potentialize PMN 
      stimulation by fMLP. The lipid moiety of the lipoproteins might be mainly 
      involved in these effects. The binding of radio-labelled fMLP to its specific 
      membrane receptor was significantly enhanced in the presence of VLDL and only 
      slightly in the presence of LDL. The study of the signal transduction suggests 
      that modulation of phospholipase D and A2 activities could be involved in the 
      modification by LDL of PMN response to fMLP.
FAU - Couderc, R
AU  - Couderc R
AD  - Laboratoire de Biochimie, Hopital Tenon, Paris, France.
FAU - Bonneau, C
AU  - Bonneau C
FAU - Tissot, M
AU  - Tissot M
FAU - Bailleul, S
AU  - Bailleul S
FAU - Roch-Arveiller, M
AU  - Roch-Arveiller M
FAU - Giroud, J P
AU  - Giroud JP
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Biofactors
JT  - BioFactors (Oxford, England)
JID - 8807441
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Lipoproteins, LDL)
RN  - 0 (Lipoproteins, VLDL)
RN  - 0 (Triglycerides)
RN  - 0 (very low density lipoprotein triglyceride)
RN  - 11062-77-4 (Superoxides)
RN  - 59880-97-6 (N-Formylmethionine Leucyl-Phenylalanine)
SB  - IM
MH  - Arteriosclerosis/blood/physiopathology
MH  - Cholesterol, LDL/blood
MH  - Humans
MH  - In Vitro Techniques
MH  - Kinetics
MH  - Lipoproteins, LDL/*blood/*pharmacology
MH  - Lipoproteins, VLDL/*blood/*pharmacology
MH  - Models, Cardiovascular
MH  - N-Formylmethionine Leucyl-Phenylalanine/pharmacology
MH  - Neutrophils/drug effects/*physiology
MH  - Superoxides/*blood
MH  - Triglycerides/pharmacology
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1002/biof.5520060209 [doi]
PST - ppublish
SO  - Biofactors. 1997;6(2):157-63. doi: 10.1002/biof.5520060209.