PMID- 9261528
OWN - NLM
STAT- MEDLINE
DCOM- 19970922
LR  - 20200203
IS  - 0923-7534 (Print)
IS  - 0923-7534 (Linking)
VI  - 8
IP  - 6
DP  - 1997 Jun
TI  - Peripheral T-cell lymphomas. Clinico-pathologic study of 168 cases diagnosed 
      according to the R.E.A.L. Classification.
PG  - 583-92
AB  - BACKGROUND: One hundred sixty-eight peripheral T-cell lymphomas (PTCLs) were 
      reviewed according to the Revised European-American Lymphoma (R.E.A.L.) 
      Classification. PATIENTS AND METHODS: The cases, originally diagnosed on the 
      basis of the Updated Kiel Classification (UKC), were all provided with 
      histological preparations, immunophenotype, clinical information, and follow-up 
      data. The slides were reclassified by five observers, who integrated the R.E.A.L. 
      criteria with cell size measurements. The prognostic value of clinical and 
      pathologic findings was assessed by univariate and multivariate analysis. 
      RESULTS: The R.E.A.L. Classification was reproducibly applied by all of the 
      observers. Clinically, anaplastic large cell lymphomas (ALCLs) differed from the 
      remaining PTCLs by mean age (29.5 vs. 52.9 years), bulky disease (52.3% vs. 
      11.3%; P = 0.000), mediastinal mass (52.7% vs. 32%; P = 0.004), and disease-free 
      survival (68.0% vs. 38.2%; P = 0.0001). Although each histological type displayed 
      specific clinical aspects, PTCLs other than ALCL were basically characterised by 
      a poor clinical outcome which was not influenced by the UKC malignancy grade. At 
      multivariate analysis, the risk of a lower complete remission rate was related to 
      bulky disease (P = 0.001), histologic group (non-ALCL) (P = 0.01), and advanced 
      stage (III-IV) (P = 0.0002). CONCLUSIONS: The present study supports the 
      classification of T-cell lymphomas proposed by the R.E.A.L. scheme.
FAU - Ascani, S
AU  - Ascani S
AD  - Service of Pathologic Anatomy, Institute of Hematology and Clinical Oncology L. & 
      A. Seragnoli-Bologna University, Italy.
FAU - Zinzani, P L
AU  - Zinzani PL
FAU - Gherlinzoni, F
AU  - Gherlinzoni F
FAU - Sabattini, E
AU  - Sabattini E
FAU - Briskomatis, A
AU  - Briskomatis A
FAU - de Vivo, A
AU  - de Vivo A
FAU - Piccioli, M
AU  - Piccioli M
FAU - Fraternali Orcioni, G
AU  - Fraternali Orcioni G
FAU - Pieri, F
AU  - Pieri F
FAU - Goldoni, A
AU  - Goldoni A
FAU - Piccaluga, P P
AU  - Piccaluga PP
FAU - Zallocco, D
AU  - Zallocco D
FAU - Burnelli, R
AU  - Burnelli R
FAU - Leoncini, L
AU  - Leoncini L
FAU - Falini, B
AU  - Falini B
FAU - Tura, S
AU  - Tura S
FAU - Pileri, S A
AU  - Pileri SA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Ann Oncol
JT  - Annals of oncology : official journal of the European Society for Medical 
      Oncology
JID - 9007735
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Lymphoma, T-Cell/*classification/diagnosis/*pathology
MH  - Male
MH  - Middle Aged
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - S0923-7534(19)48286-0 [pii]
AID - 10.1023/a:1008200307625 [doi]
PST - ppublish
SO  - Ann Oncol. 1997 Jun;8(6):583-92. doi: 10.1023/a:1008200307625.