PMID- 9261821
OWN - NLM
STAT- MEDLINE
DCOM- 19980108
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 8
IP  - 11
DP  - 1997 Jul 28
TI  - Aromatase cytochrome P450 and 5 alpha-reductase in the amygdala and cortex of 
      perinatal rats.
PG  - 2529-33
AB  - The major androgen metabolizing enzymes, aromatase cytochrome P450 and 5 
      alpha-reductase play critical role(s) in the development of sexually dimorphic 
      brain structures, the modulation of neuroendocrine function(s) and the regulation 
      of sexual and non-sexual behaviors. Using established assays, we detected 5 
      alpha-reductase and aromatase enzymatic activities in amygdala and frontal 
      cortical tissue from male and female rats during the perinatal interval (from 
      gestational day (GD) 19 to postnatal day (PND) 6). The present findings indicate 
      that 5 alpha-reductase and aromatase rates in the cortex display different enzyme 
      profiles, while in the amygdala tissue site a similar pattern is seen for both 
      enzymes during perinatal development. In general, there was a lack of sex 
      differences in the enzymatic rates. The importance these enzyme systems play in 
      generating androgen (and progesterone) steroid metabolites which influence neural 
      development and function are discussed.
FAU - Jacobson, N A
AU  - Jacobson NA
AD  - Department of Zoology, Brigham Young University, Provo, UT 84602, USA.
FAU - Ladle, D R
AU  - Ladle DR
FAU - Lephart, E D
AU  - Lephart ED
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - EC 1.14.14.1 (Aromatase)
RN  - EC 1.3.99.5 (3-Oxo-5-alpha-Steroid 4-Dehydrogenase)
SB  - IM
MH  - 3-Oxo-5-alpha-Steroid 4-Dehydrogenase/*biosynthesis
MH  - Aging/*metabolism
MH  - Amygdala/embryology/*enzymology/growth & development
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Aromatase/*biosynthesis
MH  - Embryonic and Fetal Development
MH  - Female
MH  - Frontal Lobe/embryology/*enzymology/growth & development
MH  - *Gene Expression Regulation, Developmental
MH  - *Gene Expression Regulation, Enzymologic
MH  - Male
MH  - Pregnancy
MH  - Rats
MH  - Sex Characteristics
EDAT- 1997/07/28 00:00
MHDA- 1997/07/28 00:01
CRDT- 1997/07/28 00:00
PHST- 1997/07/28 00:00 [pubmed]
PHST- 1997/07/28 00:01 [medline]
PHST- 1997/07/28 00:00 [entrez]
AID - 10.1097/00001756-199707280-00022 [doi]
PST - ppublish
SO  - Neuroreport. 1997 Jul 28;8(11):2529-33. doi: 10.1097/00001756-199707280-00022.