PMID- 9261836
OWN - NLM
STAT- MEDLINE
DCOM- 19980108
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 8
IP  - 11
DP  - 1997 Jul 28
TI  - OCAM reveals segregated mitral/tufted cell pathways in developing accessory 
      olfactory bulb.
PG  - 2607-12
AB  - Two functional subsets of vomeronasal sensory neurons project their axons to two 
      segregated zones in the accessory olfactory bulb (AOB). Using immunohistochemical 
      methods with antibodies against the novel cell adhesion molecule OCAM, we provide 
      evidence that the segregation of functional pathways is maintained at the level 
      of mitral/tufted (M/T) cells of the mouse AOB and that this pattern emerges early 
      in ontogeny. During embryonic and postnatal development OCAM was strongly 
      expressed by M/T cells in the caudal zone of the AOB where OCAM-negative 
      vomeronasal axons terminated. In contrast, rostral zone M/T cells innervated by 
      OCAM-positive vomeronasal axons displayed no or faint OCAM immunoreactivity. 
      Differential expression of OCAM in segregated M/T cell pathways suggests that 
      OCAM may be involved in defining compartments of connectivity and setting up 
      functional subdivisions in the developing AOB.
FAU - von Campenhausen, H
AU  - von Campenhausen H
AD  - Laboratory for Neuronal Recognition Molecules, Frontier Research Program, RIKEN, 
      Saitama, Japan.
FAU - Yoshihara, Y
AU  - Yoshihara Y
FAU - Mori, K
AU  - Mori K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Ncam2 protein, mouse)
RN  - 0 (Neural Cell Adhesion Molecules)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Axons/physiology/ultrastructure
MH  - Cell Adhesion Molecules/analysis/*biosynthesis
MH  - Cell Adhesion Molecules, Neuronal/analysis/*biosynthesis
MH  - *Gene Expression Regulation, Developmental
MH  - Immunohistochemistry
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Microscopy, Confocal
MH  - Nasal Septum
MH  - Neural Cell Adhesion Molecules/analysis/biosynthesis
MH  - Neurons/cytology/*physiology
MH  - Olfactory Bulb/cytology/growth & development/*physiology
MH  - Perception
MH  - Smell/*physiology
EDAT- 1997/07/28 00:00
MHDA- 1997/07/28 00:01
CRDT- 1997/07/28 00:00
PHST- 1997/07/28 00:00 [pubmed]
PHST- 1997/07/28 00:01 [medline]
PHST- 1997/07/28 00:00 [entrez]
AID - 10.1097/00001756-199707280-00037 [doi]
PST - ppublish
SO  - Neuroreport. 1997 Jul 28;8(11):2607-12. doi: 10.1097/00001756-199707280-00037.