PMID- 9263559
OWN - NLM
STAT- MEDLINE
DCOM- 19970930
LR  - 20041117
IS  - 0735-1631 (Print)
IS  - 0735-1631 (Linking)
VI  - 14
IP  - 7
DP  - 1997 Aug
TI  - Serum tumor necrosis factor-alpha in neonatal sepsis.
PG  - 401-4
AB  - Tumor necrosis factor-alpha (TNF-alpha) is thought to be an important mediator in 
      the pathogenesis of neonatal septicemia. To assess the role of TNF-alpha in 
      neonatal sepsis, serum levels of TNF-alpha were measured in a group of neonates 
      with septicemia and compared with the levels of gestational-postnatal, 
      age-matched healthy controls. The relationships between severity of infection, 
      the nature of causative microorganisms, and TNF-alpha levels were also 
      investigated in this prospective study. A total of 49 infants (25 full-term, 24 
      preterm) with proven sepsis and 40 healthy infants (20 full-term, 20 preterm) 
      were included. Serum TNF-alpha levels were measured using the TNF-alpha 
      immunoradiometric assay. The median level of TNF-alpha was found to be 
      significantly higher in infants suffering from sepsis (154 pg/mL) particularly in 
      those with septic shock (242.5 pg/mL) as compared to healthy controls (61.5 
      pg/mL) (p < 0.001). No correlation was found between TNF-alpha and postnatal 
      ages, gestational ages or birth weights of the infants. TNF-alpha levels were not 
      different in surviving and terminal neonates. Although serum, TNF-alpha levels 
      were found to be slightly higher in gram-negative septicemia, the difference was 
      not significant. These findings suggest that TNF-alpha plays an important role in 
      the pathophysiology of neonatal septicemia, but its importance as a prognostic 
      factor is not yet clear.
FAU - Atici, A
AU  - Atici A
AD  - Cukurova University Medical Faculty Department of Pediatrics, Adana, Turkey.
FAU - Satar, M
AU  - Satar M
FAU - Cetiner, S
AU  - Cetiner S
FAU - Yaman, A
AU  - Yaman A
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Am J Perinatol
JT  - American journal of perinatology
JID - 8405212
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Bacteremia/*blood/mortality/physiopathology
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - *Infant, Premature
MH  - Male
MH  - Prognosis
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Shock, Septic/*blood/mortality/physiopathology
MH  - Survival Rate
MH  - Tumor Necrosis Factor-alpha/*analysis
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1055/s-2007-994168 [doi]
PST - ppublish
SO  - Am J Perinatol. 1997 Aug;14(7):401-4. doi: 10.1055/s-2007-994168.