PMID- 9264392
OWN - NLM
STAT- MEDLINE
DCOM- 19970904
LR  - 20231213
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 11
IP  - 8
DP  - 1997 Aug
TI  - A new breakpoint, telomeric to TEL/ETV6, on the short arm of chromosome 12 in T 
      cell acute lymphoblastic leukemia.
PG  - 1360-3
AB  - Abnormalities of the short arm of chromosome 12 frequently involve the TEL/ETV6 
      gene in acute leukemias. In two cases of T cell acute lymphoblastic leukemia with 
      translocation t(12;14)(p13;q11) and t(7;12)(q35;p13), respectively, the 
      breakpoints were located telomeric to the TEL/ETV6 locus. Further fluorescence in 
      situ hybridization (FISH) studies showed that the breakpoint was located between 
      two markers, FGF6 (centromeric) and D12S983 (telomeric) on 12p in both patients. 
      This result suggests that a new chromosomal breakpoint can nonrandomly involve 
      rearrangements in T cell malignancies. The breakpoint on chromosome 14 was 
      localized centromeric to the TRCA/D locus.
FAU - Le Coniat, M
AU  - Le Coniat M
AD  - Unite INSERM U 301 and SD 401 No 301 CNRS, Institut de Genetique Moleculaire, 
      Paris, France.
FAU - Della Valle, V
AU  - Della Valle V
FAU - Marynen, P
AU  - Marynen P
FAU - Berger, R
AU  - Berger R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Genetic Markers)
RN  - 0 (Proto-Oncogene Proteins c-ets)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adult
MH  - Chromosome Aberrations/*genetics
MH  - Chromosome Banding
MH  - Chromosome Disorders
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 12
MH  - DNA-Binding Proteins/genetics
MH  - Genetic Markers
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Leukemia-Lymphoma, Adult T-Cell/*genetics
MH  - Male
MH  - Proto-Oncogene Proteins c-ets
MH  - *Repressor Proteins
MH  - Transcription Factors/genetics
MH  - Translocation, Genetic
MH  - ETS Translocation Variant 6 Protein
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1038/sj.leu.2400737 [doi]
PST - ppublish
SO  - Leukemia. 1997 Aug;11(8):1360-3. doi: 10.1038/sj.leu.2400737.