PMID- 9264439 OWN - NLM STAT- MEDLINE DCOM- 19970904 LR - 20190622 IS - 0002-9149 (Print) IS - 0002-9149 (Linking) VI - 80 IP - 3 DP - 1997 Aug 1 TI - Persistence of human leukocyte antigen (HLA) antibodies after one year in children receiving cryopreserved valved allografts. PG - 358-9 AB - This study shows that the broad anti-HLA antibody response against cryopreserved valved allografts used for surgical repair of congenital heart disease persists beyond 1 year after implantation. In 3 patients, there were clearly defined HLA antibody specificities consistent with the HLA phenotypes of the patients, i.e., the panel-reactive antibody was directed against major alloantigen groups that were not expressed by the antibody responders. FAU - Shaddy, R E AU - Shaddy RE AD - Department of Pediatrics, University of Utah School of Medicine and Primary Childrens Medical Center, Salt Lake City 84113, USA. FAU - Thompson, D D AU - Thompson DD FAU - Osborne, K A AU - Osborne KA FAU - Hawkins, J A AU - Hawkins JA FAU - Fuller, T C AU - Fuller TC LA - eng GR - MO1-RR00064/RR/NCRR NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Am J Cardiol JT - The American journal of cardiology JID - 0207277 RN - 0 (Epitopes) RN - 0 (Histocompatibility Antigens Class I) RN - 0 (Isoantibodies) SB - IM MH - Adolescent MH - Aortic Valve/*transplantation MH - Child MH - Child, Preschool MH - Cryopreservation MH - *Epitopes MH - Heart Defects, Congenital/*surgery MH - Histocompatibility Antigens Class I/*immunology MH - Humans MH - Infant MH - Infant, Newborn MH - Isoantibodies/*blood MH - Prospective Studies MH - Pulmonary Valve/*transplantation MH - Time Factors MH - Transplantation, Homologous EDAT- 1997/08/01 00:00 MHDA- 1997/08/01 00:01 CRDT- 1997/08/01 00:00 PHST- 1997/08/01 00:00 [pubmed] PHST- 1997/08/01 00:01 [medline] PHST- 1997/08/01 00:00 [entrez] AID - S0002914997003664 [pii] AID - 10.1016/s0002-9149(97)00366-4 [doi] PST - ppublish SO - Am J Cardiol. 1997 Aug 1;80(3):358-9. doi: 10.1016/s0002-9149(97)00366-4.