PMID- 9266465
OWN - NLM
STAT- MEDLINE
DCOM- 19971020
LR  - 20190831
IS  - 0340-5354 (Print)
IS  - 0340-5354 (Linking)
VI  - 244
IP  - 7
DP  - 1997 Jul
TI  - Human herpes virus 6 and human herpes virus 8 DNA sequences in brains of multiple 
      sclerosis patients, normal adults and children.
PG  - 450-4
AB  - In order to determine whether the newly discovered human herpesviruses (HHVs) are 
      involved in multiple sclerosis (MS), we investigated by polymerase chain reaction 
      the presence of specific deoxyribonucleic acid (DNA) sequences belonging to human 
      herpesvirus 6 (HHV-6) and to human herpesvirus 8 (HHV-8), in the peripheral blood 
      mononuclear cells (PBMCs), and in the brain and spinal cord plaques from MS 
      patients. Normal adult and stillborn children's brains were investigated as 
      controls. PBMCs from 56 MS patients contained HHV-6 DNA in only 3 cases and in 
      none were there HHV-8 sequences. The cerebral DNA from 5 MS patients was positive 
      for HHV-8 and not for HHV-6 sequences, while the nervous tissue of one patient 
      who died with neuromyelitis optica was positive for HHV-6 and negative for HHV-8. 
      The brains of 4/8 adult controls were positive for HHV-6, as were 3/8 for HHV-8; 
      none of the 7 stillborn children's cerebral tissue contained HHV-6 sequences, 
      while 2 contained HHV-8 DNA. Although these data do not support a hypothesis that 
      there is a role for these two HHVs in the pathogenesis of MS, nevertheless it may 
      be suggested that (1) the two viruses possess strong neurotropism and the central 
      nervous system seems to be a reservoir for them (2) HHV-6 infection is probably 
      not transmitted maternally, but is acquired later in infancy.
FAU - Merelli, E
AU  - Merelli E
AD  - Department of Neurology, University of Modena, Italy.
FAU - Bedin, R
AU  - Bedin R
FAU - Sola, P
AU  - Sola P
FAU - Barozzi, P
AU  - Barozzi P
FAU - Mancardi, G L
AU  - Mancardi GL
FAU - Ficarra, G
AU  - Ficarra G
FAU - Franchini, G
AU  - Franchini G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - J Neurol
JT  - Journal of neurology
JID - 0423161
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Brain/*virology
MH  - Brain Chemistry
MH  - DNA, Viral/*analysis
MH  - Female
MH  - Herpesvirus 6, Human/*genetics
MH  - Herpesvirus 8, Human/*genetics
MH  - Humans
MH  - Infant, Newborn
MH  - Leukocytes, Mononuclear/virology
MH  - Male
MH  - Multiple Sclerosis/*virology
MH  - Polymerase Chain Reaction
MH  - Spinal Cord/virology
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - 10.1007/s004150050121 [doi]
PST - ppublish
SO  - J Neurol. 1997 Jul;244(7):450-4. doi: 10.1007/s004150050121.