PMID- 9266552
OWN - NLM
STAT- MEDLINE
DCOM- 19971021
LR  - 20080116
IS  - 0174-304X (Print)
IS  - 0174-304X (Linking)
VI  - 28
IP  - 3
DP  - 1997 Jun
TI  - Cerebral magnetic resonance imaging and mental and motor function of very low 
      birth weight children at six years of age.
PG  - 149-54
AB  - In this follow-up study, 20 of a geographically based year cohort of 31 surviving 
      non-disabled VLBW (birthweight < 1500 g) children were examined at six years of 
      age. The aim of the study was to relate cerebral MRI findings to 
      neuro-development in these non-disabled children at six years of age. All MRI 
      scans were evaluated for myelination pattern, periventricular gliosis, 
      ventricular dilation and cortical atrophy. The Peabody motor test and the 
      Wechsler Preschool and Primary Scale of Intelligence (WPPSI) were used in the 
      evaluation of motor, mental and perceptual function. A diagnosis of attention 
      deficit disorder with hyperactivity was made based on the examiner's impression 
      of the child during the examination and based on the parent's history. We found 
      that ten (50%) of the children had periventricular gliosis, mainly in centrum 
      semiovale (CS) (nine children) and in central occipital white matter (COW) (six 
      children). Gliosis in CS was related to lower scores on the Peabody gross motor 
      test for locomotion, indicating involvement of corticospinal tracts. Additional 
      gliosis in COW was related to both fine motor and gross motor impairments. We 
      speculate that this indicates damage to both motor and visual pathways, affecting 
      eye-hand coordination and balance function. No relationship between MRI 
      deviations at six years and mental function based on performance, verbal and 
      total IQ scores was found. However, there was a significant relationship between 
      periventricular gliosis in COW and C5 and low scores on the WPPSI performance 
      subtests: Picture completion test and Block design test. This may indicate visual 
      and spatial perception problems, caused by damage to posterior visual pathways 
      and occipito-thalamic tracts dealing with visuo-motor integration.
FAU - Skranes, J S
AU  - Skranes JS
AD  - Department of Pediatrics, University Hospital of Trondheim, Norway.
FAU - Vik, T
AU  - Vik T
FAU - Nilsen, G
AU  - Nilsen G
FAU - Smevik, O
AU  - Smevik O
FAU - Andersson, H W
AU  - Andersson HW
FAU - Brubakk, A M
AU  - Brubakk AM
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Neuropediatrics
JT  - Neuropediatrics
JID - 8101187
SB  - IM
MH  - Analysis of Variance
MH  - Cerebral Cortex/growth & development/*pathology
MH  - Chi-Square Distribution
MH  - Child Development/*physiology
MH  - Cognition/*physiology
MH  - Cohort Studies
MH  - Follow-Up Studies
MH  - Gliosis/pathology
MH  - Humans
MH  - Infant, Newborn
MH  - Infant, Very Low Birth Weight/*growth & development
MH  - Leukomalacia, Periventricular/pathology/physiopathology
MH  - Magnetic Resonance Imaging
MH  - Motor Skills/physiology
MH  - Myelin Sheath/physiology
MH  - Occipital Lobe/pathology/physiopathology
MH  - Perceptual Disorders/etiology/pathology
MH  - Psychomotor Disorders/etiology/pathology
MH  - Psychomotor Performance/*physiology
MH  - Visual Perception/physiology
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.1055/s-2007-973692 [doi]
PST - ppublish
SO  - Neuropediatrics. 1997 Jun;28(3):149-54. doi: 10.1055/s-2007-973692.