PMID- 9266946
OWN - NLM
STAT- MEDLINE
DCOM- 19970918
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 98
IP  - 2
DP  - 1997 Aug
TI  - PML/RAR alpha rearrangement in acute promyelocytic leukaemia with t(1;17) 
      elucidated using fluorescence in situ hybridization.
PG  - 440-3
AB  - Acute promyelocytic leukaemia (APL) is characterized by t(15;17)(q22;q21) which 
      results in the formation of two chimaeric genes, PML/RAR alpha and RAR alpha/PML, 
      thought to play a role in leukaemogenesis. We report a case of a patient with APL 
      apparently lacking the t(15;17) but with t(1;17) translocation identified by 
      fluorescence in situ hybridization (FISH). Chromosome 15 seemed intact but 
      PML/RAR alpha fusion transcript was detected by molecular analysis. The patient 
      achieved complete remission with all-trans retinoic acid treatment associated 
      with chemotherapy. This case illustrates the usefulness of combined cytogenetics, 
      FISH and molecular biology in cases with no evident t(15;17) to predict response 
      to treatment.
FAU - Eclache, V
AU  - Eclache V
AD  - Department of Haematology and Cytogenetics, Jean Verdier Hospital, Bondy, France.
FAU - Benzacken, B
AU  - Benzacken B
FAU - Le Roux, G
AU  - Le Roux G
FAU - Casassus, P
AU  - Casassus P
FAU - Chomienne, C
AU  - Chomienne C
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein)
SB  - IM
CIN - Br J Haematol. 1997 Dec;99(3):711-2. PMID: 9401094
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 17/*genetics
MH  - Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Promyelocytic, Acute/*genetics
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*genetics
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Polymerase Chain Reaction
MH  - *Translocation, Genetic
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1046/j.1365-2141.1997.2253042.x [doi]
PST - ppublish
SO  - Br J Haematol. 1997 Aug;98(2):440-3. doi: 10.1046/j.1365-2141.1997.2253042.x.