PMID- 9267880
OWN - NLM
STAT- MEDLINE
DCOM- 19971006
LR  - 20191024
IS  - 0888-0018 (Print)
IS  - 0888-0018 (Linking)
VI  - 14
IP  - 5
DP  - 1997 Sep-Oct
TI  - Cryptococcal meningitis following a thrombotic microangiopathy in an unrelated 
      donor bone marrow transplant recipient.
PG  - 469-74
AB  - In patients undergoing bone marrow transplantation cryptococcosis is rarely 
      encountered. We report a fatal case of Cryptococcus meningitis in a 12-year-old 
      girl with acute lymphoblastic leukemia (ALL) in second remission who had a 
      transplant from a human leukocyte antigen (HLA)-identical unrelated bone marrow 
      donor. The conditioning regimen was thiotepa, cyclophosphamide, and total body 
      irradiation (TBI); graft-versus-host disease (GVHD) prophylaxis consisted of 
      cyclosporin A, methotrexate, and antilymphocyte globulin (ALG). The patient 
      experienced stage III GVHD responsive to high-dose corticosteroids. On day +54 a 
      thrombotic microangiopathy occurred. On day +64 neurological status worsened; a 
      brain computed tomographic (CT) scan showed hyperdense lesions suggesting fungal 
      infection. Detection of cryptococcal antigen by latex agglutination was positive 
      but India ink stain and culture were negative. Despite treatment with 
      amphotericin B, 5-flucytosine, and granulocyte-macrophage colony-stimulating 
      factor, the patient died 13 days after the diagnosis.
FAU - Miniero, R
AU  - Miniero R
AD  - Department of Paediatrics, University of Turin, Italy.
FAU - Nesi, F
AU  - Nesi F
FAU - Vai, S
AU  - Vai S
FAU - De Intinis, G
AU  - De Intinis G
FAU - Papalia, F
AU  - Papalia F
FAU - Targhetta, R
AU  - Targhetta R
FAU - Busca, A
AU  - Busca A
FAU - Vassallo, E
AU  - Vassallo E
FAU - Giacchino, M
AU  - Giacchino M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Pediatr Hematol Oncol
JT  - Pediatric hematology and oncology
JID - 8700164
SB  - IM
MH  - Bone Marrow Transplantation/*adverse effects
MH  - Child
MH  - Fatal Outcome
MH  - Female
MH  - Histocompatibility Testing
MH  - Humans
MH  - Meningitis, Cryptococcal/*etiology/physiopathology
MH  - Microcirculation/pathology
MH  - Thrombosis/*etiology/*physiopathology
MH  - Tissue Donors
MH  - Transplantation, Homologous
EDAT- 1997/09/01 00:00
MHDA- 1997/09/01 00:01
CRDT- 1997/09/01 00:00
PHST- 1997/09/01 00:00 [pubmed]
PHST- 1997/09/01 00:01 [medline]
PHST- 1997/09/01 00:00 [entrez]
AID - 10.3109/08880019709028778 [doi]
PST - ppublish
SO  - Pediatr Hematol Oncol. 1997 Sep-Oct;14(5):469-74. doi: 10.3109/08880019709028778.