PMID- 9268093
OWN - NLM
STAT- MEDLINE
DCOM- 19971114
LR  - 20220408
IS  - 0148-7299 (Print)
IS  - 0148-7299 (Linking)
VI  - 71
IP  - 3
DP  - 1997 Aug 22
TI  - Hyperlipidemia, insulin-dependent diabetes mellitus, and rapidly progressive 
      diabetic retinopathy and nephropathy in Prader-Willi syndrome with 
      del(15)(q11.2q13).
PG  - 267-70
AB  - We report on a white man with Prader-Willi syndrome (PWS) and del(15)(q11.2q13), 
      confirmed by fluorescence in situ hybridization (FISH), who had hyperlipidemia, 
      insulin-dependent diabetes, and the early onset and rapid progression of diabetic 
      retinopathy and nephropathy within 4 years after diagnosis of diabetes. The 
      spectrum of glucose intolerance in patients with PWS is discussed, as well as 
      those references which suggest that the prevalence of hyperlipoproteinemia in 
      this condition may be greater than previously recognized. We suggest the need for 
      clarification of both the prevalence and types of hyperlipoproteinemia, as well 
      as the pathophysiology of glucose intolerance and correlation with molecular 
      cytogenetic findings. We also encourage careful monitoring for diabetic 
      complications to further clarify the prevalence and possible accelerated course 
      of microvascular lesions.
FAU - Bassali, R
AU  - Bassali R
AD  - Department of Pediatrics, Medical College of Georgia, Augusta 30912, USA.
FAU - Hoffman, W H
AU  - Hoffman WH
FAU - Chen, H
AU  - Chen H
FAU - Tuck-Muller, C M
AU  - Tuck-Muller CM
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Med Genet
JT  - American journal of medical genetics
JID - 7708900
SB  - IM
MH  - Adult
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 15/*genetics
MH  - Diabetes Mellitus, Type 1/*complications/*genetics
MH  - Diabetic Nephropathies/*complications/*genetics
MH  - Diabetic Retinopathy/*complications/*genetics
MH  - Glucose Intolerance/genetics
MH  - Humans
MH  - Hyperlipidemias/*complications/*genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Prader-Willi Syndrome/*complications/*genetics
MH  - Time Factors
EDAT- 1997/08/22 00:00
MHDA- 2000/06/20 09:00
CRDT- 1997/08/22 00:00
PHST- 1997/08/22 00:00 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1997/08/22 00:00 [entrez]
AID - 10.1002/(SICI)1096-8628(19970822)71:3<267::AID-AJMG3>3.0.CO;2-R [pii]
PST - ppublish
SO  - Am J Med Genet. 1997 Aug 22;71(3):267-70.