PMID- 9269613
OWN - NLM
STAT- MEDLINE
DCOM- 19971010
LR  - 20181130
IS  - 1120-009X (Print)
IS  - 1120-009X (Linking)
VI  - 9
IP  - 4
DP  - 1997 Aug
TI  - Vinorelbine chemotherapy in non small cell lung cancer: experience in elderly 
      patients.
PG  - 304-8
AB  - This study involved 25 elderly (> 65 years old) patients (pts) with unresectable 
      non small cell lung cancer (NSCLC) who were not eligible for polychemotherapy. 
      The diagnosis of NSCLC was histologically or cytologically documented, and all of 
      them had measurable or evaluable disease. The median age of the patients was 71 
      (range 65-77); 9 had been pretreated. The pts received 25 mg/m2 of vinorelbine 
      weekly or bi-weekly depending on the results of blood tests. The treatment 
      continued until disease progression or tolerance. No complete response was 
      achieved: 3 pts (12%) had a partial response (RP) (8-12-14 months), 13 (52%) 
      stable disease (SD) with an improvement in symptoms, such as cough and/or pain, 
      and 9 pts (36%) progressed. Compliance with the therapy was acceptable. The main 
      toxicity was hematological: neutropenia was observed in 16 pts, with only 1 case 
      of grade 4 neutropenia without sepsis; grade 1-2 anemia occurred in 8 patients. 
      The other toxicities included grade 1-2 neurotoxicity in 8 pts, chemical 
      phlebitis in 2 pts and grade 3 cardiotoxicity reversible with medical treatment 
      in 1 patient. The median survival time was 10 months (lower quartile 5 months, 
      upper quartile 23 months) (Kaplan and Meyer method). Vinorelbine can be 
      considered a rational choice in elderly pts with advanced NSCLC who are not 
      suitable for aggressive polychemotherapy, with the aim of improving their quality 
      of life in terms of symptoms and outpatient treatment.
FAU - Tononi, A
AU  - Tononi A
AD  - Division of Oncology, Ospedale Infermi, Rimini, Italy.
FAU - Panzini, I
AU  - Panzini I
FAU - Oliverio, G
AU  - Oliverio G
FAU - Pasquini, E
AU  - Pasquini E
FAU - Gianni, L
AU  - Gianni L
FAU - Nicolini, M
AU  - Nicolini M
FAU - Ravaioli, A
AU  - Ravaioli A
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Chemother
JT  - Journal of chemotherapy (Florence, Italy)
JID - 8907348
RN  - 0 (Antineoplastic Agents, Phytogenic)
RN  - 5V9KLZ54CY (Vinblastine)
RN  - Q6C979R91Y (Vinorelbine)
SB  - IM
MH  - Aged
MH  - Anemia/chemically induced
MH  - Antineoplastic Agents, Phytogenic/adverse effects/*therapeutic use
MH  - Carcinoma, Non-Small-Cell Lung/diagnostic imaging/*drug therapy/pathology
MH  - Female
MH  - Humans
MH  - Leukopenia/chemically induced
MH  - Lung Neoplasms/diagnostic imaging/*drug therapy/pathology
MH  - Male
MH  - Neutropenia/chemically induced
MH  - Quality of Life
MH  - Survival Analysis
MH  - Tomography, X-Ray Computed
MH  - Treatment Outcome
MH  - Vinblastine/adverse effects/*analogs & derivatives/therapeutic use
MH  - Vinorelbine
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1179/joc.1997.9.4.304 [doi]
PST - ppublish
SO  - J Chemother. 1997 Aug;9(4):304-8. doi: 10.1179/joc.1997.9.4.304.