PMID- 9269617
OWN - NLM
STAT- MEDLINE
DCOM- 19971016
LR  - 20191111
IS  - 0748-1977 (Print)
IS  - 0748-1977 (Linking)
VI  - 13
IP  - 4
DP  - 1997 Jul
TI  - Near continuous cardiac output by thermodilution.
PG  - 233-9
AB  - A new thermodilution method for frequent (near continuous) estimation of cardiac 
      output, without manual injection of fluid into the blood, was tested. The method 
      utilizes a pulmonary artery catheter equipped with a fluid filled heat exchanger. 
      The technique is based on cyclic cooling of the blood in the right atrium and 
      measurement of the temperature changes in the pulmonary artery. Using this 
      technique, a new estimate of cardiac output can be obtained every 32 s. Cardiac 
      output estimates, obtained for a running mean of three measurements with this 
      method, were compared to the mean of three conventional thermodilution 
      measurements. The measurements were obtained during short periods of stable 
      respiration and circulation. In six pigs, we made 46 paired measurements of 
      conventional thermodilution (TD) and near continuous (TDc) thermodilution. The 
      cardiac output (COTD) ranged from 2.4-13.7 l/min (mean 5.4 l/min). The best 
      linear fit through the paired data points was COTDc = -0.57 + 1.01 COTD. The mean 
      difference between the methods was -0.50 l/min (S.D. = 0.39). The mean 
      coefficient of variation of repeated measurements with the near continuous 
      thermodilution was 3.6%. Considering changes of more than 0.25 l/min to be 
      significant, all changes in cardiac output measured by conventional 
      thermodilution were followed by the running mean of three near continuous 
      thermodilution estimates. This study demonstrates the feasibility of the new 
      method to monitor cardiac output, and to detect all changes greater than 0.25 
      l/min.
FAU - Jansen, J R
AU  - Jansen JR
AD  - Department of Pulmonary Diseases, Erasmus University, Rotterdam, The Netherlands.
FAU - Johnson, R W
AU  - Johnson RW
FAU - Yan, J Y
AU  - Yan JY
FAU - Verdouw, P D
AU  - Verdouw PD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - J Clin Monit
JT  - Journal of clinical monitoring
JID - 8506707
RN  - 451W47IQ8X (Sodium Chloride)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Blood Circulation
MH  - Blood Physiological Phenomena
MH  - Blood Pressure
MH  - Blood Volume
MH  - Body Temperature/physiology
MH  - Cardiac Output/*physiology
MH  - Catheterization, Swan-Ganz/instrumentation
MH  - Central Venous Pressure
MH  - Cold Temperature
MH  - Feasibility Studies
MH  - Female
MH  - Heart Atria
MH  - Hot Temperature
MH  - Linear Models
MH  - Male
MH  - *Monitoring, Intraoperative
MH  - Oxygen/blood
MH  - Positive-Pressure Respiration
MH  - Pulmonary Artery
MH  - Sodium Chloride/administration & dosage
MH  - Swine
MH  - Thermodilution/*methods
MH  - Tidal Volume
MH  - Time Factors
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
AID - 10.1023/a:1007332517810 [doi]
PST - ppublish
SO  - J Clin Monit. 1997 Jul;13(4):233-9. doi: 10.1023/a:1007332517810.