PMID- 9269754
OWN - NLM
STAT- MEDLINE
DCOM- 19970924
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 90
IP  - 4
DP  - 1997 Aug 15
TI  - Human immunodeficiency virus-1 entry into purified blood dendritic cells through 
      CC and CXC chemokine coreceptors.
PG  - 1379-86
AB  - Blood dendritic cells (DC) are susceptible to both macrophage (M) and T-cell line 
      (T) tropic human immunodeficiency virus type 1. The CC chemokines RANTES, 
      macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, eotaxin, and, to 
      a lesser extent, monocyte chemoattractant protein-1 (MCP-1) and MCP-4 blocked 
      entry of M-tropic virus into blood DC. The CXC chemokine, SDF-1, a fusin (CXCR4 
      chemokine receptor) ligand, and an antifusin antibody inhibited DC entry by 
      T-tropic virus. Purified blood DC contained CCR1, CCR2, CCR3, and CCR5 as well as 
      the CXCR4 chemokine receptor RNA transcripts and high levels of fusin on the cell 
      surface. The coexpression of multiple chemokine receptors offers a molecular 
      mechanism to explain the permissiveness of DC for both M- and T-tropic viruses.
FAU - Ayehunie, S
AU  - Ayehunie S
AD  - Laboratory of Viral Pathogenesis, Dana-Farber Cancer Institute and Harvard 
      Medical School, Boston, MA 02115, USA.
FAU - Garcia-Zepeda, E A
AU  - Garcia-Zepeda EA
FAU - Hoxie, J A
AU  - Hoxie JA
FAU - Horuk, R
AU  - Horuk R
FAU - Kupper, T S
AU  - Kupper TS
FAU - Luster, A D
AU  - Luster AD
FAU - Ruprecht, R M
AU  - Ruprecht RM
LA  - eng
GR  - R01-AI-34266/AI/NIAID NIH HHS/United States
GR  - R01-AI32330/AI/NIAID NIH HHS/United States
GR  - R01-CA69212/CA/NCI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (CCL11 protein, human)
RN  - 0 (Chemokine CCL11)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines, CC)
RN  - 0 (Chemotactic Factors, Eosinophil)
RN  - 0 (Cytokines)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, CXCR4)
RN  - 0 (Receptors, Cytokine)
RN  - 0 (Receptors, HIV)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Chemokine CCL11
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Chemokine CCL5/metabolism
MH  - *Chemokines, CC
MH  - Chemotactic Factors, Eosinophil/metabolism
MH  - Cytokines/metabolism
MH  - Dendritic Cells/metabolism/*virology
MH  - Flow Cytometry
MH  - GTP-Binding Proteins/metabolism
MH  - HIV-1/metabolism/*pathogenicity
MH  - Humans
MH  - In Vitro Techniques
MH  - Macrophage Inflammatory Proteins/metabolism
MH  - Membrane Proteins/metabolism
MH  - Receptors, CXCR4
MH  - Receptors, Cytokine/*metabolism
MH  - Receptors, HIV/*metabolism
MH  - T-Lymphocytes/virology
EDAT- 1997/08/15 00:00
MHDA- 1997/08/15 00:01
CRDT- 1997/08/15 00:00
PHST- 1997/08/15 00:00 [pubmed]
PHST- 1997/08/15 00:01 [medline]
PHST- 1997/08/15 00:00 [entrez]
AID - S0006-4971(20)58052-X [pii]
PST - ppublish
SO  - Blood. 1997 Aug 15;90(4):1379-86.