PMID- 9270550
OWN - NLM
STAT- MEDLINE
DCOM- 19970915
LR  - 20101118
IS  - 0190-9622 (Print)
IS  - 0190-9622 (Linking)
VI  - 37
IP  - 2 Pt 3
DP  - 1997 Aug
TI  - The genetics of psoriasis.
PG  - S1-11
AB  - The analysis of population-specific human leukocyte antigen (HLA) haplotypes has 
      provided evidence that susceptibility to psoriasis is linked to the class I and 
      II major histo-compatibility complex on human chromosome 6. In addition, these 
      studies show that psoriasis consists of two distinct disease subtypes (type I and 
      type II), which differ in age of onset and in the frequency of HLA. In type I 
      (early-onset) psoriasis, Cw6, B57, and DR7 are strongly increased, whereas in 
      type II (late-onset) psoriasis, HLA-Cw2 is overrepresented. It has also been 
      proposed that HLA haplotypes extended by class III play a role in the genetics of 
      this disease. Moreover, studies of affected families indicate that other disease 
      susceptibility loci may also be involved. Likely candidates for additional 
      susceptibility genes are located at chromosomes 1, 6, and 17, and microsatellite 
      markers over the whole genome have been used to identify susceptibility genes. 
      Two years ago linkage to the distal part of chromosome 17 was published. However, 
      this linkage could not be confirmed by other groups with comparable or enlarged 
      numbers of psoriatic family members investigated. Recently, an investigation 
      presenting an area of chromosome 4 as a susceptibility locus for psoriasis was 
      published. According to our knowledge today, psoriasis is a polygenetically 
      inherited disease. Furthermore from twin studies it is known that environmental 
      factors play a significant role in the onset or recurrence of the disease.
FAU - Henseler, T
AU  - Henseler T
AD  - Department of Dermatology, University of Kiel, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Chromosomes, Human, Pair 17/genetics
MH  - Chromosomes, Human, Pair 6/genetics
MH  - Disease Susceptibility
MH  - Genetic Linkage/genetics
MH  - HLA Antigens/genetics
MH  - Haplotypes
MH  - Humans
MH  - Phenotype
MH  - Psoriasis/classification/etiology/*genetics
RF  - 80
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - S0190-9622(97)80394-5 [pii]
PST - ppublish
SO  - J Am Acad Dermatol. 1997 Aug;37(2 Pt 3):S1-11.