PMID- 9271359
OWN - NLM
STAT- MEDLINE
DCOM- 19970905
LR  - 20190516
IS  - 0892-6638 (Print)
IS  - 0892-6638 (Linking)
VI  - 11
IP  - 10
DP  - 1997 Aug
TI  - Journey from cachexia to obesity by TNF.
PG  - 743-51
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a cytokine involved in the 
      physiological and metabolic abnormalities found in cachectic states. Until very 
      recently, it was inconceivable to think of TNF-alpha in obesity. However, recent 
      studies have shown that TNF-alpha can also play a key role in obesity, the 
      cytokine being overexpressed in adipose tissue of obese rodents and humans. The 
      aim of this review is to reconcile the role of TNF-alpha in these two opposite 
      metabolic situations: obesity and cachexia. It is suggested that TNF-alpha may 
      have a key role in the control of body mass in normal weight-controlled 
      situations and that abnormalities in either its production (during cachexia) or 
      action (during obesity) are responsible for the lack of control of body weight.
FAU - Argiles, J M
AU  - Argiles JM
AD  - Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat 
      de Barcelona, Spain.
FAU - Lopez-Soriano, J
AU  - Lopez-Soriano J
FAU - Busquets, S
AU  - Busquets S
FAU - Lopez-Soriano, F J
AU  - Lopez-Soriano FJ
LA  - eng
PT  - Historical Article
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - FASEB J
JT  - FASEB journal : official publication of the Federation of American Societies for 
      Experimental Biology
JID - 8804484
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adipocytes/physiology
MH  - Adipose Tissue/physiology
MH  - Body Temperature Regulation
MH  - Cachexia/*physiopathology
MH  - Diabetes Mellitus, Type 2/physiopathology
MH  - History, 19th Century
MH  - History, 20th Century
MH  - Homeostasis
MH  - Humans
MH  - Insulin Resistance
MH  - Obesity/*physiopathology
MH  - Tumor Necrosis Factor-alpha/history/*physiology
RF  - 107
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1096/fasebj.11.10.9271359 [doi]
PST - ppublish
SO  - FASEB J. 1997 Aug;11(10):743-51. doi: 10.1096/fasebj.11.10.9271359.