PMID- 9272177
OWN - NLM
STAT- MEDLINE
DCOM- 19970925
LR  - 20190722
IS  - 0340-6717 (Print)
IS  - 0340-6717 (Linking)
VI  - 100
IP  - 3-4
DP  - 1997 Sep
TI  - Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A 
      (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate 
      gene for multiple endocrine neoplasia type 1 (MEN1).
PG  - 481-5
AB  - The multiple endocrine neoplasia type 1 (MEN1) locus has been previously 
      localised to 11q13 by combined tumour deletion mapping and recombination studies, 
      and a 0.5-Mb region, flanked by PYGM and D11S449, has been defined. In the course 
      of constructing a conting, we have identified the location of the gene encoding 
      the B56 beta subunit of protein phosphatase 2A (PP2A), which is involved in cell 
      signal transduction pathways and thus represents a candidate gene for MEN1. We 
      have searched for mutations in the PP2A-B56 beta coding region, together with the 
      5' and 3' untranslated regions in six MEN1 patients. DNA sequence abnormalities 
      were not identified and thus the PP2A-B56 beta gene is excluded as the candidate 
      gene for MEN1. However, our precise localisation of PP2A-B56 beta to this region 
      of 11q13 may help in elucidating the basis for other disease genes mapping to 
      this generich region.
FAU - Forbes, S A
AU  - Forbes SA
AD  - MRC Molecular Endocrinology Group, Royal Postgraduate Medical School, Hammersmith 
      Hospital, London, UK.
FAU - Pannett, A A
AU  - Pannett AA
FAU - Bassett, J H
AU  - Bassett JH
FAU - Harding, B
AU  - Harding B
FAU - Wooding, C
AU  - Wooding C
FAU - Thakker, R V
AU  - Thakker RV
FAU - Butler, R
AU  - Butler R
FAU - Ogilvie, D
AU  - Ogilvie D
FAU - Anand, R
AU  - Anand R
FAU - Gaudray, P
AU  - Gaudray P
FAU - Weber, G
AU  - Weber G
FAU - Larsson, C
AU  - Larsson C
FAU - Zhang, C X
AU  - Zhang CX
FAU - Calender, A
AU  - Calender A
FAU - Hoppener, J W
AU  - Hoppener JW
FAU - Lips, C J
AU  - Lips CJ
FAU - Kas, K
AU  - Kas K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Hum Genet
JT  - Human genetics
JID - 7613873
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - EC 3.1.3.16 (Phosphoprotein Phosphatases)
RN  - EC 3.1.3.16 (Protein Phosphatase 2)
SB  - IM
MH  - Chromosome Mapping
MH  - Chromosomes, Artificial, Yeast
MH  - *Chromosomes, Human, Pair 11
MH  - Gene Library
MH  - Humans
MH  - Multiple Endocrine Neoplasia Type 1/*genetics
MH  - Neoplasm Proteins/*genetics
MH  - Phosphoprotein Phosphatases/*genetics
MH  - Protein Phosphatase 2
MH  - *Proto-Oncogene Proteins
EDAT- 1997/09/01 00:00
MHDA- 1997/09/01 00:01
CRDT- 1997/09/01 00:00
PHST- 1997/09/01 00:00 [pubmed]
PHST- 1997/09/01 00:01 [medline]
PHST- 1997/09/01 00:00 [entrez]
AID - 10.1007/s004390050538 [doi]
PST - ppublish
SO  - Hum Genet. 1997 Sep;100(3-4):481-5. doi: 10.1007/s004390050538.