PMID- 9272939
OWN - NLM
STAT- MEDLINE
DCOM- 19971023
LR  - 20190822
IS  - 0903-1936 (Print)
IS  - 0903-1936 (Linking)
VI  - 10
IP  - 8
DP  - 1997 Aug
TI  - Rhinitis caused by ninhydrin develops into occupational asthma.
PG  - 1918-21
AB  - Ninhydrin (2,2-dihydroxy-1,3-indanedione or 1,2,3-triketo-hydrindene hydrate) is 
      a chemical used in the detection of free amino and carboxyl groups in proteins 
      and peptides. Allergic, immunoglobulin E (IgE)-mediated rhinitis caused by 
      ninhydrin was diagnosed earlier in a 41 yr old woman working as a laboratory 
      technician in a forensic laboratory. Despite handling ninhydrin only in a flow 
      cabinet, symptoms of dyspnoea developed 6 months later. Peak flow was found to 
      vary by 20% during working days. In the specific inhalation challenge it was 
      shown that occupational asthma had also developed due to continuing slight 
      exposure to ninhydrin. The titre of ninhydrin-specific IgE also increased from 
      0.6 to 1.1 kU x L(-1) in the follow-up. This case stresses the importance of 
      cessation of allergen exposure in occupational allergic rhinitis, in order to 
      prevent asthma.
FAU - Piirila, P
AU  - Piirila P
AD  - Finnish Institute of Occupational Health, Helsinki.
FAU - Estlander, T
AU  - Estlander T
FAU - Hytonen, M
AU  - Hytonen M
FAU - Keskinen, H
AU  - Keskinen H
FAU - Tupasela, O
AU  - Tupasela O
FAU - Tuppurainen, M
AU  - Tuppurainen M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Eur Respir J
JT  - The European respiratory journal
JID - 8803460
RN  - 37341-29-0 (Immunoglobulin E)
RN  - HCL6S9K23A (Ninhydrin)
SB  - IM
MH  - Adult
MH  - Asthma/*chemically induced
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/physiology
MH  - Medical Laboratory Personnel
MH  - Ninhydrin/*adverse effects
MH  - Occupational Diseases/*chemically induced
MH  - Rhinitis, Allergic, Perennial/*chemically induced
MH  - Time Factors
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - 10.1183/09031936.97.10081918 [doi]
PST - ppublish
SO  - Eur Respir J. 1997 Aug;10(8):1918-21. doi: 10.1183/09031936.97.10081918.