PMID- 9276079
OWN - NLM
STAT- MEDLINE
DCOM- 19971017
LR  - 20071114
IS  - 0006-3223 (Print)
IS  - 0006-3223 (Linking)
VI  - 42
IP  - 5
DP  - 1997 Sep 1
TI  - Mismatch negativity during attend and ignore conditions in Alzheimer's disease.
PG  - 382-402
AB  - Mismatch negativities (MMNs) of the event-related potential to deviant tones and 
      environmental sounds were recorded during active and ignore oddball sequences in 
      young and elderly controls and patients with probable Alzheimer's disease (PAD). 
      MMNs were smaller in the PAD waveforms compared to those of the controls, 
      suggesting a degraded sensory memory trace in these subjects; however, under 
      ignore conditions, environmental sounds elicited robust MMNs in the PAD group 
      along with N2b and novelty P3 components in similar fashion to controls. As N2b 
      and P3 are usually elicited by attended stimuli, these data suggest that in the 
      PAD subjects, the highly deviant events involuntarily captured attention, perhaps 
      reflecting the activation of an attentional switching mechanism. Because this 
      passive switching is thought to reflect activation of a mechanism located in the 
      frontal lobes, the data suggest that this putative frontal lobe mechanism is 
      relatively intact in the early stages of the disease.
FAU - Kazmerski, V A
AU  - Kazmerski VA
AD  - Department of Psychology, Behrend College, Erie, Pennsylvania, USA.
FAU - Friedman, D
AU  - Friedman D
FAU - Ritter, W
AU  - Ritter W
LA  - eng
GR  - AG 09988/AG/NIA NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
SB  - IM
MH  - Acoustic Stimulation
MH  - Adult
MH  - Aged
MH  - Alzheimer Disease/*psychology
MH  - Attention/*physiology
MH  - Electroencephalography
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Reference Values
EDAT- 1997/09/01 00:00
MHDA- 1997/09/01 00:01
CRDT- 1997/09/01 00:00
PHST- 1997/09/01 00:00 [pubmed]
PHST- 1997/09/01 00:01 [medline]
PHST- 1997/09/01 00:00 [entrez]
AID - S0006-3223(96)00344-7 [pii]
AID - 10.1016/S0006-3223(96)00344-7 [doi]
PST - ppublish
SO  - Biol Psychiatry. 1997 Sep 1;42(5):382-402. doi: 10.1016/S0006-3223(96)00344-7.