PMID- 9276526
OWN - NLM
STAT- MEDLINE
DCOM- 19970909
LR  - 20190512
IS  - 0009-9104 (Print)
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 109
IP  - 2
DP  - 1997 Aug
TI  - Antibodies to beta2-glycoprotein I--a specific marker for the antiphospholipid 
      syndrome.
PG  - 304-9
AB  - The antiphospholipid syndrome is a disorder characterized by recurrent thrombosis 
      and the presence of antibodies specific to phospholipids. However, the diagnosis 
      of this syndrome is hampered by the lack of a specific laboratory test. In this 
      study an ELISA for the measurement of antibodies to solid-phase 
      beta2-glycoprotein I (beta2-GPI) was established and compared with 
      anticardiolipin antibodies for diagnosis of antiphospholipid syndrome. 
      Significantly elevated levels of antibodies to beta2-GPI were found in all 
      patients with definite antiphospholipid syndrome (median = 91 AU). Marginally 
      elevated levels of antibodies to beta2-GPI were observed in 5% of patients with 
      systemic lupus erythematosus (SLE; median = 4 AU), 1% with stroke (median = 3 
      AU), 13% with infectious mononucleosis (median = 3 AU), 10% with HIV infection 
      (median = 3 AU) and 8% with VDRL false-positive serology for syphilis (median = 4 
      AU), but not in patients with rheumatoid factor, syphilis or carotid artery 
      stenosis. In contrast, significantly raised levels of anticardiolipin antibodies 
      were observed in 100% of patients with definite antiphospholipid syndrome, 30% 
      with SLE, 88% with HIV infection, 94% with syphilis, 62% with infectious 
      mononucleosis, 9% with rheumatoid factor-positive sera, 74% VDRL false-positive 
      serology for syphilis, 47% with stroke and 0% with carotid artery stenosis. This 
      solid-phase assay for antibodies to beta2-GPI is highly specific for the 
      antiphospholipid syndrome and represents an advance in the laboratory diagnosis 
      of this disorder.
FAU - Guerin, J
AU  - Guerin J
AD  - Department of Immunology, St James' Hospital, Dublin, Ireland.
FAU - Feighery, C
AU  - Feighery C
FAU - Sim, R B
AU  - Sim RB
FAU - Jackson, J
AU  - Jackson J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Antibodies, Anticardiolipin)
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
RN  - 0 (Glycoproteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
MH  - Antibodies, Anticardiolipin/analysis
MH  - Antiphospholipid Syndrome/*diagnosis
MH  - *Autoantibodies/analysis
MH  - Biomarkers/analysis
MH  - Cerebrovascular Disorders/diagnosis
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - False Positive Reactions
MH  - Glycoproteins/*immunology
MH  - HIV Infections/diagnosis
MH  - Humans
MH  - Infectious Mononucleosis/diagnosis
MH  - Lupus Erythematosus, Systemic/diagnosis
MH  - Membrane Glycoproteins/*immunology
MH  - Syphilis/diagnosis
MH  - beta 2-Glycoprotein I
PMC - PMC1904736
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
PMCR- 1998/08/01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
PHST- 1998/08/01 00:00 [pmc-release]
AID - 10.1046/j.1365-2249.1997.4601357.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 1997 Aug;109(2):304-9. doi: 10.1046/j.1365-2249.1997.4601357.x.