PMID- 9276968
OWN - NLM
STAT- MEDLINE
DCOM- 19970929
LR  - 20150901
IS  - 0255-6596 (Print)
IS  - 0255-6596 (Linking)
VI  - 21
IP  - 2
DP  - 1997 Apr
TI  - Identification of classic and complex t(15;17) and/or RAR alpha/PML gene fusion 
      in APL by cytogenetic and dual color-FISH techniques.
PG  - 54-60
AB  - Acute promyelocytic leukemia (APL) is a malignant condition characterized by 
      t(15;17)(q22;q12), which fuses the PML gene on chromosome 15 to the retinoic acid 
      receptor alpha (RAR alpha) gene on chromosome 17. In this study, t(15;17) was 
      identified cytogenetically by using the conventional cytogenetic technique, and 
      its molecular counterpart RAR alpha/PML fusion on chromosome 17 on interphase 
      nuclei was further confirmed by means of dual color- (DC-) fluorescence in situ 
      hybridization (FISH) on serial bone marrow (BM) and peripheral blood (PB) samples 
      from APL patients at different stages of the disease. Overall, our findings 
      indicate that interphase DC-FISH analysis can be a useful technique as an adjunct 
      to conventional cytogenetic investigation for detecting the presence of RAR 
      alpha/PML fusion in APL.
FAU - Acar, H
AU  - Acar H
AD  - Department of Medical Genetics, Selcuk University, Faculty of Medicine, Konya, 
      Turkey.
FAU - Dundar, M
AU  - Dundar M
FAU - Stewart, J
AU  - Stewart J
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Proc Natl Sci Counc Repub China B
JT  - Proceedings of the National Science Council, Republic of China. Part B, Life 
      sciences
JID - 8502426
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Bone Marrow/pathology
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 15/*genetics/ultrastructure
MH  - Chromosomes, Human, Pair 17/*genetics/ultrastructure
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Leukemia, Promyelocytic, Acute/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Proteins/*genetics
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Oncogenes
MH  - *Translocation, Genetic
EDAT- 1997/04/01 00:00
MHDA- 1997/04/01 00:01
CRDT- 1997/04/01 00:00
PHST- 1997/04/01 00:00 [pubmed]
PHST- 1997/04/01 00:01 [medline]
PHST- 1997/04/01 00:00 [entrez]
PST - ppublish
SO  - Proc Natl Sci Counc Repub China B. 1997 Apr;21(2):54-60.