PMID- 9278140
OWN - NLM
STAT- MEDLINE
DCOM- 19980105
LR  - 20131121
IS  - 1431-6730 (Print)
IS  - 1431-6730 (Linking)
VI  - 378
IP  - 7
DP  - 1997 Jul
TI  - Oxygen(es) and the hypoxia-inducible factor-1.
PG  - 609-16
AB  - The hypoxia-inducible factor-1 (HIF-1) is a basic-helix-loop-helix (bHLH) 
      heterodimeric transcription factor activated by reductions in oxygen 
      concentration (hypoxia). Activated HIF-1 upregulates expression of genes involved 
      in the adaptation of higher organisms to hypoxic conditions, caused by e.g. high 
      altitude, anemia, wound healing or during development. Examples of these 
      oxy-genes include erythropoietin, a hormone regulating erythropoiesis and hence 
      the oxygen transport capacity, and vascular endothelial growth factor, a potent 
      inducer of angiogenesis leading to increased blood capillary density. The HIF-1 
      heterodimer is composed of a HIF-1alpha and an ARNT subunit, both belonging to 
      the explosively growing PAS subfamily of bHLH transcription factors. Closely 
      related, but differentially expressed, factors have recently been cloned, at 
      least one of which can also be activated by hypoxia. In this review, we present a 
      survey of the bH LH-PAS family as well as of the genes regulated by HIF-1, and we 
      summarize our current knowledge on the oxygen-dependent activation of this 
      fascinating transcription factor.
FAU - Wenger, R H
AU  - Wenger RH
AD  - Institute of Physiology, University of Zurich-Irchel, Switzerland.
FAU - Gassmann, M
AU  - Gassmann M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Biol Chem
JT  - Biological chemistry
JID - 9700112
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Cell Hypoxia/*genetics
MH  - DNA-Binding Proteins/*genetics
MH  - Helix-Loop-Helix Motifs/*genetics
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Nuclear Proteins/*genetics
MH  - Oxygen/*metabolism
MH  - Transcription Factors/*genetics
RF  - 61
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
PST - ppublish
SO  - Biol Chem. 1997 Jul;378(7):609-16.