PMID- 9278775
OWN - NLM
STAT- MEDLINE
DCOM- 19971020
LR  - 20191102
IS  - 0144-1795 (Print)
IS  - 0144-1795 (Linking)
VI  - 17
IP  - 3
DP  - 1997 Jun
TI  - Intracerebroventricular choline reverses hypotension induced by acute chemical 
      sympathectomy.
PG  - 155-63
AB  - 1. The effect of centrally administered choline on blood pressure was 
      investigated in rats made hypotensive by chemical sympathectomy. Chemical 
      sympathectomy was produced by intravenous (i.v.) injection of 50 mg kg-1 of 
      6-hydroxydopamine (6-OHDA). Intracerebroventricular (i.c.v.) administration of 
      choline (50-150 micrograms) 2 h after 6-OHDA treatment increased blood pressure 
      and reversed the hypotension in a dose-dependent manner without affecting the 
      heart rate. The pressor response was associated with an increase in plasma 
      vasopressin levels. 2. Pretreatment of rats with the nicotinic receptor 
      antagonist, mecamylamine (50 micrograms, i.c.v.), but not the muscarinic receptor 
      antagonist atropine (10 micrograms, i.c.v.), blocked both the pressor and 
      vasopressin responses to choline (150 micrograms). Pretreatment of rats with 
      hemicholinium-3 (HC-3), a high affinity choline uptake inhibitor, greatly 
      attenuated the pressor response to i.c.v. choline (150 micrograms). 3. The 
      vasopressin V1 receptor antagonist, 
      beta-mercapto-beta,beta-cyclopentamethylenepropionyl-O-Me-Try,Arg) - vasopressin 
      (10 micrograms kg-1; i.v.) given 5 min after i.c.v. choline, decreased the blood 
      pressure but failed to return it to the pre-choline levels. Prazosine (0.5 mg 
      kg-1; i.p.), an antagonist of alpha-adrenoceptors, also decreased blood pressure. 
      Administration of both antagonists together eliminated the pressor response to 
      choline, and the blood pressure was reduced further to below the pre-choline 
      levels. 4. It is concluded that i.c.v. choline can increase blood pressure in 
      rats made hypotensive by acute chemical sympathectomy through the activation of 
      central nicotinic receptors by presynaptic mechanisms. An elevation in plasma 
      levels of both vasopressin and catecholamines (possibly released from the adrenal 
      medulla) is involved in the pressor response to choline.
FAU - Gurun, M S
AU  - Gurun MS
AD  - Department of Pharmacology, Uludag University Medical Faculty, Bursa, Turkey.
FAU - Savci, V
AU  - Savci V
FAU - Ulus, I H
AU  - Ulus IH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Auton Pharmacol
JT  - Journal of autonomic pharmacology
JID - 8106455
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Cholinergic Antagonists)
RN  - 0 (Receptors, Cholinergic)
RN  - 11000-17-2 (Vasopressins)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - N91BDP6H0X (Choline)
RN  - XM03YJ541D (Prazosin)
SB  - IM
MH  - Adrenergic alpha-Antagonists/pharmacology
MH  - Animals
MH  - Blood Pressure/*drug effects/*physiology
MH  - Choline/*pharmacology
MH  - Cholinergic Antagonists/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Heart Rate/drug effects
MH  - Hypotension/etiology
MH  - Injections, Intravenous
MH  - Injections, Intraventricular
MH  - Male
MH  - Oxidopamine
MH  - Prazosin/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Cholinergic/drug effects
MH  - *Sympathectomy, Chemical
MH  - Vasopressins/antagonists & inhibitors/blood
EDAT- 1997/06/01 00:00
MHDA- 1997/06/01 00:01
CRDT- 1997/06/01 00:00
PHST- 1997/06/01 00:00 [pubmed]
PHST- 1997/06/01 00:01 [medline]
PHST- 1997/06/01 00:00 [entrez]
AID - 10.1046/j.1365-2680.1997.00450.x [doi]
PST - ppublish
SO  - J Auton Pharmacol. 1997 Jun;17(3):155-63. doi: 10.1046/j.1365-2680.1997.00450.x.