PMID- 92797
OWN - NLM
STAT- MEDLINE
DCOM- 19800228
LR  - 20190823
IS  - 0033-2917 (Print)
IS  - 0033-2917 (Linking)
VI  - 9
IP  - 4
DP  - 1979 Nov
TI  - Is schizophrenia an HLA-associated disease?
PG  - 721-8
AB  - Certain specificities of the human leukocyte antigen (HLA) system have been shown 
      to be associated with particular diseases. A review of recent studies in 
      schizophrenia shows inconsistent results for schizophrenia as a whole, although a 
      significant increase in HLA A28 remains on combining the data. There are more 
      consistent findings for disease subtypes. In particular, HLA A9 and HLA CW4 are 
      increased in paranoid schizophrenics, while HLA A1 and the A1-B8 haplotype are 
      increased in nuclear forms. It is postulated that the relationship between the 
      schizophrenias and certain HLA types could be due to an influence of the latter 
      upon neuronal post-synaptic membrane sensitivity to central neurotransmitters 
      such as dopamine.
FAU - McGuffin, P
AU  - McGuffin P
LA  - eng
PT  - Journal Article
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
RN  - 0 (Receptors, Dopamine)
RN  - U42B7VYA4P (Chlorpromazine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Antigen-Antibody Reactions
MH  - Antipsychotic Agents/pharmacology
MH  - Chlorpromazine/therapeutic use
MH  - Dopamine/metabolism
MH  - Epitopes
MH  - HLA Antigens/*analysis
MH  - Humans
MH  - Mice
MH  - Receptors, Dopamine/drug effects/immunology/metabolism
MH  - Schizophrenia/drug therapy/*immunology
MH  - Schizophrenia, Paranoid/immunology
EDAT- 1979/11/01 00:00
MHDA- 1979/11/01 00:01
CRDT- 1979/11/01 00:00
PHST- 1979/11/01 00:00 [pubmed]
PHST- 1979/11/01 00:01 [medline]
PHST- 1979/11/01 00:00 [entrez]
AID - 10.1017/s0033291700034036 [doi]
PST - ppublish
SO  - Psychol Med. 1979 Nov;9(4):721-8. doi: 10.1017/s0033291700034036.