PMID- 9281224
OWN - NLM
STAT- MEDLINE
DCOM- 19970902
LR  - 20061115
IS  - 0042-8809 (Print)
IS  - 0042-8809 (Linking)
VI  - 43
IP  - 1
DP  - 1997 Jan-Feb
TI  - [Immunochemical correlates of the severity of Parkinson's disease].
PG  - 34-8
AB  - The serum samples from 29 patients with Parkinson's disease were analysed for the 
      levels of the autoantibodies (a-AB) and antiidiotype antibodies (AIAB) to the 
      proteins of nervous system S-100, GFAP, NKP and MP-65. High levels of a-AB or 
      AIAB to at least 3 proteins were seen in patients with severe course of the 
      disease. No significant changes of these levels were observed in patients with 
      light course of the disease. The plasmapheresis was carried out to some patients 
      with severe course of the disease. After this procedure the decrease of 
      neurological deficit from number 21 +/- 2 to 8 +/- 1 on Webster's scale and 
      decrease of a-AB and AIAB levels to normal values (in some cases it became lower 
      than normal values) were observed. It can be concluded that the levels of the 
      a-AB to the nervous tissue proteins correlate with clinical condition of the 
      patient.
FAU - Morozov, S G
AU  - Morozov SG
FAU - Ivanova-Smolenskaia, I A
AU  - Ivanova-Smolenskaia IA
FAU - Markova, E D
AU  - Markova ED
FAU - Piradov, M A
AU  - Piradov MA
FAU - Poleshchuk, V V
AU  - Poleshchuk VV
FAU - Labunskii, D A
AU  - Labunskii DA
FAU - Gnedenko, B B
AU  - Gnedenko BB
LA  - rus
PT  - English Abstract
PT  - Journal Article
TT  - Immunokhimicheskie korreliaty tiazhesti techeniia bolezni Parkinsona.
PL  - Russia (Federation)
TA  - Vopr Med Khim
JT  - Voprosy meditsinskoi khimii
JID - 0416601
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Autoantibodies)
RN  - 0 (Glial Fibrillary Acidic Protein)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Anti-Idiotypic/*blood
MH  - Autoantibodies/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Glial Fibrillary Acidic Protein/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Nerve Tissue Proteins/*immunology
MH  - Parkinson Disease/blood/*immunology
MH  - S100 Proteins/immunology
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
PST - ppublish
SO  - Vopr Med Khim. 1997 Jan-Feb;43(1):34-8.