PMID- 9281463
OWN - NLM
STAT- MEDLINE
DCOM- 19971002
LR  - 20161124
IS  - 1046-2023 (Print)
IS  - 1046-2023 (Linking)
VI  - 13
IP  - 1
DP  - 1997 Sep
TI  - Allergen source materials and quality control of allergenic extracts.
PG  - 2-13
AB  - Allergen extracts are prepared from a wide variety of source materials including 
      pollens, fungi, arthropods, animal danders, foods, and dusts. The composition of 
      allergen extracts can vary depending on the allergen source, manufacturing 
      process, and storage conditions. Allergen-specific immunoglobulin E (IgE) assays 
      and skin tests employ a variety of allergen-containing reagents that confer 
      specificity on the test. Given that the allergen source materials are 
      heterogenous mixtures of proteins, glycoproteins, carbohydrates, and other 
      substances that are not allergenic, it is not unexpected that variability exists 
      between test results obtained with different allergen-containing reagents. 
      Variability within a single manufacturer's allergen product can be controlled by 
      using reproducible extraction and processing procedures, single large lots of 
      allergen source materials, and solid-phase supports. These controls do not, 
      however, ensure the consistency of products between manufacturers or laboratories 
      because allergen source materials, manufacturing procedures, and acceptance 
      criteria for allergen reagents may vary.
FAU - Esch, R E
AU  - Esch RE
AD  - Greer Laboratories, Inc., Lenoir, North Carolina 28645, USA.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Methods
JT  - Methods (San Diego, Calif.)
JID - 9426302
RN  - 0 (Allergens)
RN  - 0 (Amb a I protein, Ambrosia artemisiifolia)
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (Antigens, Plant)
RN  - 0 (Glycoproteins)
RN  - 0 (Immune Sera)
RN  - 0 (Plant Extracts)
RN  - 0 (Plant Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - G408EE88II (Fel d 1 protein, Felis domesticus)
SB  - IM
MH  - *Allergens/immunology/isolation & purification
MH  - Animals
MH  - Antigens, Dermatophagoides
MH  - Antigens, Plant
MH  - Cats
MH  - Drug Approval
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Glycoproteins/immunology/standards
MH  - Humans
MH  - Immune Sera
MH  - Immunoglobulin E/blood
MH  - Plant Extracts/immunology/standards
MH  - Plant Proteins/immunology/standards
MH  - Pollen/immunology
MH  - Quality Control
MH  - Reference Standards
MH  - Saliva/immunology
MH  - Skin/immunology
MH  - United States
MH  - United States Food and Drug Administration
EDAT- 1997/09/01 00:00
MHDA- 1997/09/01 00:01
CRDT- 1997/09/01 00:00
PHST- 1997/09/01 00:00 [pubmed]
PHST- 1997/09/01 00:01 [medline]
PHST- 1997/09/01 00:00 [entrez]
AID - S1046-2023(97)90491-6 [pii]
AID - 10.1006/meth.1997.0491 [doi]
PST - ppublish
SO  - Methods. 1997 Sep;13(1):2-13. doi: 10.1006/meth.1997.0491.