PMID- 9283219
OWN - NLM
STAT- MEDLINE
DCOM- 19971024
LR  - 20151119
IS  - 0385-2385 (Print)
IS  - 0385-2385 (Linking)
VI  - 39
IP  - 5
DP  - 1997 Jul
TI  - [A case of myeloperoxidase-antineutrophil cytoplasmic antibody (ANCA)-positive 
      crescentic glomerulonephritis induced by propylthiouracil (PTU)].
PG  - 517-22
AB  - We have experienced a case of myeloperoxidase-antineutrophil cytoplasmic antibody 
      (MPO-ANCA)-related glomerulonephritis induced by propylthiouracil (PTU). A 
      45-year-old female had been treated with PTU for 4 years after the diagnosis of 
      hyperthyroidism. She was referred to out hospital because of abrupt macroscopic 
      hematuria and moderate proteinuria after several days of upper respiratory tract 
      infection. On admission, her laboratory findings showed deterioration of renal 
      function. Renal biopsy revealed crescentic glomerulonephritis without deposition 
      of immune complexes. Her serology was found to be MPO-ANCA-positive and 
      cytoplasmic-ANCA-negative. Based of these findings, we diagnosed idiopathic 
      crescentic glomerulonephritis. Following the initiation of steroid pulse therapy, 
      her urinary protein excretion and renal function gradually improved in parallel 
      with a decrease in the MPO-ANCA titer. Although steroid therapy effectively 
      responded to their renal function without the withdrawal of PTU, it seems that 
      PTU may be closely associated with the development of (MPO-ANCA)-related 
      glomerulonephritis in this case. Therefore, hyperthyroidism patients treated with 
      PTU should be paced under vigilant observation by monitoring their urinalysis and 
      serum creatinine level.
FAU - Kato, H
AU  - Kato H
AD  - Second Department of Internal Medicine University of Occupational and 
      Environmental Health, School of Medicine, Kitakyushu, Japan.
FAU - Osajima, A
AU  - Osajima A
FAU - Tanaka, H
AU  - Tanaka H
FAU - Serino, R
AU  - Serino R
FAU - Kabashima, N
AU  - Kabashima N
FAU - Tamura, M
AU  - Tamura M
FAU - Segawa, K
AU  - Segawa K
FAU - Anai, H
AU  - Anai H
FAU - Takasugi, M
AU  - Takasugi M
FAU - Nakajima, Y
AU  - Nakajima Y
LA  - jpn
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Nihon Jinzo Gakkai Shi
JT  - Nihon Jinzo Gakkai shi
JID - 7505731
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
RN  - 0 (Antithyroid Agents)
RN  - 0 (Biomarkers)
RN  - 721M9407IY (Propylthiouracil)
RN  - EC 1.11.1.7 (Peroxidase)
SB  - IM
MH  - Antibodies, Antineutrophil Cytoplasmic/*analysis
MH  - Antithyroid Agents/*adverse effects
MH  - Biomarkers/analysis
MH  - Female
MH  - Glomerulonephritis/*chemically induced/pathology
MH  - Humans
MH  - Hyperthyroidism/drug therapy
MH  - Middle Aged
MH  - Peroxidase/*analysis
MH  - Propylthiouracil/*adverse effects
RF  - 20
EDAT- 1997/07/01 00:00
MHDA- 1997/07/01 00:01
CRDT- 1997/07/01 00:00
PHST- 1997/07/01 00:00 [pubmed]
PHST- 1997/07/01 00:01 [medline]
PHST- 1997/07/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Jinzo Gakkai Shi. 1997 Jul;39(5):517-22.