PMID- 9284528
OWN - NLM
STAT- MEDLINE
DCOM- 19971016
LR  - 20061115
IS  - 1044-579X (Print)
IS  - 1044-579X (Linking)
VI  - 7
IP  - 6
DP  - 1996 Dec
TI  - HLA control in the progression of human papillomavirus infections.
PG  - 359-71
AB  - Cellular immunity is likely to be of major importance for the clearance of 
      inapparent or overt infections caused by human papillomaviruses (HPVs). The 
      highly polymorphic class I or class II human leukocyte antigen (HLA) molecules 
      present HPV-derived peptides to cytotoxic (CD8+) or helper (CD4+) T lymphocytes 
      bearing specific receptors and condition the immune responsiveness to HPV 
      infections. Recent data point to a role of an altered expression of HLA molecules 
      in the persistence of HPV-induced cervical premalignant lesions and their 
      progression towards invasive carcinoma. Furthermore positive of negative 
      associations of certain HLA alleles or haplotypes with cutaneous of cervical 
      neoplasias have been found. These observations may have important implications in 
      the design of therapy or vaccines aimed at eradicating cervical cancer.
FAU - Breitburd, F
AU  - Breitburd F
AD  - Unite Mixte Institut Pasteur/INSERM (U190), Institut Pasteur, Paris, France.
FAU - Ramoz, N
AU  - Ramoz N
FAU - Salmon, J
AU  - Salmon J
FAU - Orth, G
AU  - Orth G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Semin Cancer Biol
JT  - Seminars in cancer biology
JID - 9010218
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Animals
MH  - Disease Progression
MH  - Down-Regulation
MH  - HLA Antigens/genetics/*immunology
MH  - Histocompatibility Antigens Class I/immunology
MH  - Histocompatibility Antigens Class II/immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - *Papillomaviridae
MH  - Papillomavirus Infections/*immunology/physiopathology
MH  - Rabbits
RF  - 120
EDAT- 1996/12/01 00:00
MHDA- 1996/12/01 00:01
CRDT- 1996/12/01 00:00
PHST- 1996/12/01 00:00 [pubmed]
PHST- 1996/12/01 00:01 [medline]
PHST- 1996/12/01 00:00 [entrez]
AID - S1044-579X(96)90045-0 [pii]
AID - 10.1006/scbi.1996.0045 [doi]
PST - ppublish
SO  - Semin Cancer Biol. 1996 Dec;7(6):359-71. doi: 10.1006/scbi.1996.0045.