PMID- 9285412
OWN - NLM
STAT- MEDLINE
DCOM- 19970929
LR  - 20220318
IS  - 1074-7613 (Print)
IS  - 1074-7613 (Linking)
VI  - 7
IP  - 2
DP  - 1997 Aug
TI  - LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes.
PG  - 283-90
AB  - In the present study, we describe a novel inhibitory receptor, 
      leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1), that is 
      constitutively expressed on the majority of human peripheral blood mononuclear 
      leukocytes. LAIR-1 is a 32 kDa transmembrane glycoprotein with a single 
      immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor 
      tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases 
      upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) 
      cells results in strong inhibition of NK cell-mediated cytotoxicity. Although it 
      is structurally related to human killer cell inhibitory receptors, LAIR-1 does 
      not appear to recognize human leukocyte antigen (HLA) class I molecules and thus 
      represents a novel HLA class I-independent mechanism of NK cell regulation.
FAU - Meyaard, L
AU  - Meyaard L
AD  - Department of Immunobiology, DNAX Research Institute of Molecular and Cellular 
      Biology, Palo Alto, California 94304-1104, USA.
FAU - Adema, G J
AU  - Adema GJ
FAU - Chang, C
AU  - Chang C
FAU - Woollatt, E
AU  - Woollatt E
FAU - Sutherland, G R
AU  - Sutherland GR
FAU - Lanier, L L
AU  - Lanier LL
FAU - Phillips, J H
AU  - Phillips JH
LA  - eng
SI  - GENBANK/AF013249
SI  - GENBANK/AF013250
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Immunity
JT  - Immunity
JID - 9432918
RN  - 0 (DNA, Complementary)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (leukocyte-associated immunoglobulin-like receptor 1)
RN  - EC 3.1.3.48 (PTPN11 protein, human)
RN  - EC 3.1.3.48 (PTPN6 protein, human)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 11)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatase, Non-Receptor Type 6)
RN  - EC 3.1.3.48 (Protein Tyrosine Phosphatases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - DNA, Complementary/isolation & purification
MH  - HL-60 Cells
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins
MH  - Jurkat Cells
MH  - Killer Cells, Natural/metabolism
MH  - Leukocytes, Mononuclear/*metabolism
MH  - Molecular Sequence Data
MH  - Protein Binding/immunology
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 11
MH  - Protein Tyrosine Phosphatase, Non-Receptor Type 6
MH  - Protein Tyrosine Phosphatases/metabolism
MH  - RNA, Messenger/biosynthesis
MH  - Receptors, Immunologic/*biosynthesis/chemistry/genetics/*physiology
MH  - Tumor Cells, Cultured
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
AID - S1074-7613(00)80530-0 [pii]
AID - 10.1016/s1074-7613(00)80530-0 [doi]
PST - ppublish
SO  - Immunity. 1997 Aug;7(2):283-90. doi: 10.1016/s1074-7613(00)80530-0.