PMID- 9285733
OWN - NLM
STAT- MEDLINE
DCOM- 19971118
LR  - 20161124
IS  - 0301-0449 (Print)
IS  - 0301-0449 (Linking)
VI  - 27
IP  - 9
DP  - 1997 Sep
TI  - Childhood moyamoya disease: hemodynamic MRI.
PG  - 727-35
AB  - BACKGROUND: Childhood moyamoya disease is a rare progressive cerebrovascular 
      disease. OBJECTIVE: To evaluate cerebral hemodynamics using dynamic 
      Gd-DTPA-enhanced imaging in children with moyamoya disease. MATERIALS AND 
      METHODS: Eight children (2-11 years of age) with the clinical and angiographic 
      findings typical of moyamoya disease, before and/or after surgical intervention 
      (pial synangiosis), underwent conventional MR imaging (MRI) and hemodynamic MR 
      imaging (HMRI). HMRI used a spoiled gradient-echo with low flip angle (10 deg) 
      and long TE (TR/TE = 24/15 ms) to minimize T 1 effects and emphasize T 2* 
      weighting. Raw and calculated hemodynamic images were reviewed. Three-dimensional 
      time-of-flight MR angiography (MRA) and perfusion brain single photon emission 
      computed tomography (SPECT) were also performed. RESULTS: Abnormal hemodynamic 
      maps resulting from vascular stenosis or occlusion and basal collaterals were 
      observed in six patient studies. HMRI depicted perfusion dynamics of affected 
      cerebrovascular territories, detected cortical perfusion deficits, and 
      complemented conventional MRI and MRA. HMRI findings were consistent with those 
      of catheter angiography and perfusion SPECT. CONCLUSION: Our preliminary 
      experience suggests that HMRI may be of value in the preoperative and 
      postoperative evaluation of surgical interventions in moyamoya disease.
FAU - Tzika, A A
AU  - Tzika AA
AD  - Department of Radiology, Children's Hospital and Harvard Medical School, 300 
      Longwood Avenue, Boston, MA 02115, USA.
FAU - Robertson, R L
AU  - Robertson RL
FAU - Barnes, P D
AU  - Barnes PD
FAU - Vajapeyam, S
AU  - Vajapeyam S
FAU - Burrows, P E
AU  - Burrows PE
FAU - Treves, S T
AU  - Treves ST
FAU - Scott, R M
AU  - Scott RM
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Pediatr Radiol
JT  - Pediatric radiology
JID - 0365332
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Brain/diagnostic imaging
MH  - *Cerebrovascular Circulation
MH  - Child
MH  - Child, Preschool
MH  - Contrast Media
MH  - Female
MH  - Gadolinium DTPA
MH  - Hemodynamics
MH  - Humans
MH  - Magnetic Resonance Angiography
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Moyamoya Disease/diagnostic imaging/*physiopathology
MH  - Tomography, Emission-Computed, Single-Photon
EDAT- 1997/09/12 00:00
MHDA- 1997/09/12 00:01
CRDT- 1997/09/12 00:00
PHST- 1997/09/12 00:00 [pubmed]
PHST- 1997/09/12 00:01 [medline]
PHST- 1997/09/12 00:00 [entrez]
AID - 10.1007/s002470050212 [doi]
PST - ppublish
SO  - Pediatr Radiol. 1997 Sep;27(9):727-35. doi: 10.1007/s002470050212.