PMID- 9286119
OWN - NLM
STAT- MEDLINE
DCOM- 19970930
LR  - 20061115
IS  - 0393-1978 (Print)
IS  - 0393-1978 (Linking)
VI  - 42
IP  - 8
DP  - 1997 Aug
TI  - Cytogenetic aspects of cell proliferation in atherosclerotic plaques.
PG  - 833-6
AB  - Fluorescence in situ hybridization (FISH) using chromosome specific 
      alpha-satellite DNA probes for chromosome 7, was performed on paraffin-embedded 
      sections of 21 cases of human "unstable" atherosclerotic plaques, in order to 
      determine whether trisomy 7, found by some Authors with conventional 
      cytogenetics, is a biological characteristic of the atherosclerotic plaque. In 15 
      cases (71%) the FISH method showed smooth muscle cells with three or more spots. 
      In particular the trisomy 7 was the most significant and constant result. The 
      presence of an extra chromosome 7 is strictly correlated with an overexpression 
      of the gene for chain A of the platelet-derived growth factor (PDGF), which was 
      mapped at pter-7q22 region. Therefore trisomy 7 seems to correspond to an 
      increase in PDGF synthesis and consequently to an increase in proliferative 
      activity of smooth muscle cells.
FAU - Matturri, L
AU  - Matturri L
AD  - Istituto di Anatomia e Istologia Patologica, Universita degli Studi, IRCCS 
      Ospedale Maggiore, Milano.
FAU - Cazzullo, A
AU  - Cazzullo A
FAU - Turconi, P
AU  - Turconi P
FAU - Lavezzi, A M
AU  - Lavezzi AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - Cardiologia
JT  - Cardiologia (Rome, Italy)
JID - 8506637
SB  - IM
MH  - Arteriosclerosis/*genetics/pathology
MH  - Cell Division
MH  - Chromosomes, Human, Pair 7
MH  - Cytogenetics
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Trisomy
EDAT- 1997/08/01 00:00
MHDA- 1997/08/01 00:01
CRDT- 1997/08/01 00:00
PHST- 1997/08/01 00:00 [pubmed]
PHST- 1997/08/01 00:01 [medline]
PHST- 1997/08/01 00:00 [entrez]
PST - ppublish
SO  - Cardiologia. 1997 Aug;42(8):833-6.