PMID- 9286305
OWN - NLM
STAT- MEDLINE
DCOM- 19971003
LR  - 20180216
IS  - 0001-5792 (Print)
IS  - 0001-5792 (Linking)
VI  - 98
IP  - 2
DP  - 1997
TI  - Lymphotropic virus infection of peripheral blood mononuclear cells in B-cell 
      non-Hodgkin's lymphoma.
PG  - 89-94
AB  - Some lymphotropic viruses such as Epstein-Barr virus (EBV) and human herpesvirus 
      6 (HHV-6) have been proposed as causative agents of B cell non-Hodgkin's lymphoma 
      (NHL). More recently, the presence of hepatitis C virus (HCV), which is both a 
      hepatotropic and lymphotropic virus, has been reported in one third of B cell NHL 
      patients. The aim of this study was to investigate in a series of B cell NHL the 
      prevalence of three lymphotropic viruses, i.e. EBV, HHV-6 and HCV, in peripheral 
      blood mononuclear cells (PBMC). Eighteen unselected B cell NHL patients (10 men, 
      8 women; mean age 62 +/- 12 years, range 31-77 years; mean disease duration 1.8 
      +/- 1.4 years) and 40 age- and sex-matched healthy controls were included in the 
      study. In all cases, an acquired-immunodeficiency-syndrome-related lymphoma was 
      excluded. By means of the polymerase chain reaction technique, EBV DNA, HHV-6 DNA 
      and HCV RNA were detected in PBMC. HCV genomic sequences were significantly more 
      frequent in PBMC of NHL patients than in controls (33 vs. 2.5%; p < 0.01); on the 
      other hand, in the same two groups EBV DNA (39 vs. 60%; p = not significant) and 
      HHV-6 DNA (22 vs. 32%; p = not significant) were present in a comparable 
      percentage of individuals in the same two groups. The infection of PBMC by HCV 
      alone was present in the majority (5 of 6) of HCV-positive NHL. These data 
      support the implication of HCV infection in a statistically significant number of 
      B cell NHL, whereas a possible co-operation between HCV and other well-known 
      lymphotropic viruses seems to be excluded.
FAU - Ferri, C
AU  - Ferri C
AD  - Istituto Patologia Medica I, University of Pisa, Italy.
FAU - Lo Jacono, F
AU  - Lo Jacono F
FAU - Monti, M
AU  - Monti M
FAU - Caracciolo, F
AU  - Caracciolo F
FAU - La Civita, L
AU  - La Civita L
FAU - Barsanti, L A
AU  - Barsanti LA
FAU - Longombardo, G
AU  - Longombardo G
FAU - Lombardini, F
AU  - Lombardini F
FAU - Careccia, G
AU  - Careccia G
FAU - Zignego, A L
AU  - Zignego AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Acta Haematol
JT  - Acta haematologica
JID - 0141053
RN  - 0 (DNA, Viral)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - DNA, Viral/analysis
MH  - Female
MH  - Hepacivirus/genetics/*isolation & purification
MH  - Herpesvirus 4, Human/genetics/*isolation & purification
MH  - Herpesvirus 6, Human/genetics/*isolation & purification
MH  - Humans
MH  - Leukocytes, Mononuclear/*virology
MH  - Lymphoma, B-Cell/blood/*virology
MH  - Male
MH  - Middle Aged
MH  - RNA, Viral/analysis
EDAT- 1997/01/01 00:00
MHDA- 1997/01/01 00:01
CRDT- 1997/01/01 00:00
PHST- 1997/01/01 00:00 [pubmed]
PHST- 1997/01/01 00:01 [medline]
PHST- 1997/01/01 00:00 [entrez]
AID - 10.1159/000203597 [doi]
PST - ppublish
SO  - Acta Haematol. 1997;98(2):89-94. doi: 10.1159/000203597.